Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

Hong-Chang Yang, L. L. Chiu, Shu-Hsien Liao, H. H. Chen, Herng-Er Horng, C. W. Liu, C. I. Liu, K. L. Chen, M. J. Chen, L. M. Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

Original languageEnglish
Article number043911
JournalJournal of Applied Physics
Volume113
Issue number4
DOIs
Publication statusPublished - 2013 Jan 28

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dextrans
ferrofluids
proteins
nanoparticles
magnetic fields
iron oxides
protons
spin-lattice relaxation
magnetometers
phosphates
buffers
interference

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields. / Yang, Hong-Chang; Chiu, L. L.; Liao, Shu-Hsien; Chen, H. H.; Horng, Herng-Er; Liu, C. W.; Liu, C. I.; Chen, K. L.; Chen, M. J.; Wang, L. M.

In: Journal of Applied Physics, Vol. 113, No. 4, 043911, 28.01.2013.

Research output: Contribution to journalArticle

Yang, H-C, Chiu, LL, Liao, S-H, Chen, HH, Horng, H-E, Liu, CW, Liu, CI, Chen, KL, Chen, MJ & Wang, LM 2013, 'Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields', Journal of Applied Physics, vol. 113, no. 4, 043911. https://doi.org/10.1063/1.4789009
Yang, Hong-Chang ; Chiu, L. L. ; Liao, Shu-Hsien ; Chen, H. H. ; Horng, Herng-Er ; Liu, C. W. ; Liu, C. I. ; Chen, K. L. ; Chen, M. J. ; Wang, L. M. / Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields. In: Journal of Applied Physics. 2013 ; Vol. 113, No. 4.
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