Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang, L. L. Chiu, S. H. Liao, H. H. Chen, H. E. Horng, C. W. Liu, C. I. Liu, K. L. Chen, M. J. Chen, L. M. Wang

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4 Citations (Scopus)

Abstract

In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

Original languageEnglish
Article number043911
JournalJournal of Applied Physics
Volume113
Issue number4
DOIs
Publication statusPublished - 2013 Jan 28

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Yang, H. C., Chiu, L. L., Liao, S. H., Chen, H. H., Horng, H. E., Liu, C. W., Liu, C. I., Chen, K. L., Chen, M. J., & Wang, L. M. (2013). Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields. Journal of Applied Physics, 113(4), [043911]. https://doi.org/10.1063/1.4789009