Reinvestigation of the synthesis of 1-deazauridine

Cheng Hung Jen, Tun Cheng Chien

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(-d-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved.

Original languageEnglish
Pages (from-to)523-534
Number of pages12
JournalNucleosides, Nucleotides and Nucleic Acids
Volume29
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Ribose
Isomerization
pyridine
ribonolactone

Keywords

  • 1-deazauridine
  • 2,6-dimethoxypyridine
  • C-nucleoside
  • d-ribonolactone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

Cite this

Reinvestigation of the synthesis of 1-deazauridine. / Jen, Cheng Hung; Chien, Tun Cheng.

In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 29, No. 7, 01.07.2010, p. 523-534.

Research output: Contribution to journalArticle

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