Abstract
A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(-d-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved.
| Original language | English |
|---|---|
| Pages (from-to) | 523-534 |
| Number of pages | 12 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Volume | 29 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2010 Jul 1 |
Keywords
- 1-deazauridine
- 2,6-dimethoxypyridine
- C-nucleoside
- d-ribonolactone
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Genetics
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Cite this
Jen, C. H., & Chien, T. C. (2010). Reinvestigation of the synthesis of 1-deazauridine. Nucleosides, Nucleotides and Nucleic Acids, 29(7), 523-534. https://doi.org/10.1080/15257771003762170