TY - CHAP
T1 - Regulation of TOR complex 1 by amino acids through small GTPases
AU - Avruch, Joseph
AU - Long, Xiaomeng
AU - Lin, Yenshou
AU - Ortiz-Vega, Sara
AU - Rapley, Joseph
AU - Oshiro, Noriko
N1 - Funding Information:
Work cited herein from the authors’ laboratories was supported by NIH grants DK17776 (JA), CA73818 (JA) and by Scientific Research Funds of the Ministry of Education, Culture, Sports, Science and Technology of Japan and CREST, Japan Science and Technology Agency.
PY - 2010
Y1 - 2010
N2 - TOR complex 1 (TORC1), composed of the TOR (target of rapamycin) protein kinase, the substrate binding subunit raptor, and the 36. kDa WD propellor protein Lst8/GβL, controls cell growth in all eukaryotes in response to nutrient availability, and in metazoans, to insulin and growth factors, energy status, and stress conditions. This chapter will focus on the mechanisms underlying mammalian TORC1 regulation by amino acids, in the context of overall TORC1 regulation in metazoan cells.
AB - TOR complex 1 (TORC1), composed of the TOR (target of rapamycin) protein kinase, the substrate binding subunit raptor, and the 36. kDa WD propellor protein Lst8/GβL, controls cell growth in all eukaryotes in response to nutrient availability, and in metazoans, to insulin and growth factors, energy status, and stress conditions. This chapter will focus on the mechanisms underlying mammalian TORC1 regulation by amino acids, in the context of overall TORC1 regulation in metazoan cells.
UR - http://www.scopus.com/inward/record.url?scp=77954933190&partnerID=8YFLogxK
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U2 - 10.1016/S1874-6047(10)27004-X
DO - 10.1016/S1874-6047(10)27004-X
M3 - Chapter
AN - SCOPUS:77954933190
T3 - Enzymes
SP - 57
EP - 73
BT - Enzymes
PB - Academic Press
ER -