Regulation of TOR complex 1 by amino acids through small GTPases

Joseph Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Joseph Rapley, Noriko Oshiro

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

TOR complex 1 (TORC1), composed of the TOR (target of rapamycin) protein kinase, the substrate binding subunit raptor, and the 36. kDa WD propellor protein Lst8/GβL, controls cell growth in all eukaryotes in response to nutrient availability, and in metazoans, to insulin and growth factors, energy status, and stress conditions. This chapter will focus on the mechanisms underlying mammalian TORC1 regulation by amino acids, in the context of overall TORC1 regulation in metazoan cells.

Original languageEnglish
Title of host publicationEnzymes
PublisherAcademic Press
Pages57-73
Number of pages17
EditionC
DOIs
Publication statusPublished - 2010

Publication series

NameEnzymes
NumberC
Volume27
ISSN (Print)1874-6047

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biochemistry
  • Molecular Biology

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