TOR complex 1 (TORC1), composed of the TOR (target of rapamycin) protein kinase, the substrate binding subunit raptor, and the 36. kDa WD propellor protein Lst8/GβL, controls cell growth in all eukaryotes in response to nutrient availability, and in metazoans, to insulin and growth factors, energy status, and stress conditions. This chapter will focus on the mechanisms underlying mammalian TORC1 regulation by amino acids, in the context of overall TORC1 regulation in metazoan cells.
|Title of host publication||Enzymes|
|Number of pages||17|
|Publication status||Published - 2010|
ASJC Scopus subject areas
- Molecular Biology