@article{31145bfcbe12402b8e6e9aa2665dac65,
title = "Regioselective synthesis and biological evaluation of: N -substituted 2-aminoquinazolin-4-ones",
abstract = "The reaction of methyl anthranilates with N-arylcyanamides in the presence of p-TsOH in t-BuOH under reflux afforded predominantly 3-arylquinazolin-4-ones. In contrast, the reaction of the same reactants with TMSCl in t-BuOH at 60 °C followed by the Dimroth rearrangement in aqueous ethanolic sodium hydroxide gave exclusively the regioisomers, 2-(N-arylamino)quinazolin-4-ones. The regioselective synthesis of N-aryl-substituted 2-aminoquinazolin-4-ones can be further applied to the synthesis of benzimidazo[2,1-b]quinazolin-12-ones.",
author = "Liao, {Zhen Yuan} and Yeh, {Wen Hsiung} and Liao, {Pen Yuan} and Liu, {Yu Ting} and Chen, {Ying Cheng} and Chen, {Yi Hung} and Hsieh, {Tsung Han} and Lin, {Chia Chi} and Lu, {Ming Hsuan} and Chen, {Yi Song} and Hsu, {Ming Chih} and Li, {Tsai Kun} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by Research Grants MOST 106-2113-M-003-006-and MOST 105-2113-M-003-003-from the Ministry of Science and Technology, Taiwan. We also thank Mr Ting-Shen Kuo (National Taiwan Normal University) for his assistance with X-ray crystallographic analysis. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
month = jan,
day = "1",
doi = "10.1039/c8ob00624e",
language = "English",
volume = "16",
pages = "4482--4494",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "24",
}