Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention

Chiang-Ting Chien, Hong Jeng Yu, Ya Jung Cheng, Ming Shiou Wu, Chau Fong Chen, Su Ming Hsu

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Abstract

1. We examined the possibility that a vesicovascular reflex is exaggerated by acute urinary retention, and that the increase in renal vascular resistance caused by this reflex may lead to renal dysfunction. We evaluated the vesicovascular responses to normal micturition (NM, transcystometric condition) and acute urinary retention (isovolumetric condition mimicking complete bladder-outlet obstruction (CBOO) and partial urethral ligation mimicking partial bladder-outlet obstruction (PBOO)) in anaesthetized female Wistar rats. 2. Acute urinary retention due to CBOO or PBOO provoked a prolonged or increased intravesical pressure, an enhancement in both bladder pelvic afferent and bladder pelvic efferent nervous activity, and an elevation in mean arterial blood pressure. 3. Single-unit analysis showed that these vesicovascular reflexes were triggered by activation of low-threshold and high-threshold bladder mechanoreceptors, but not by renal uretropelvic mechanoreceptors. 4. Bladder contraction in CBOO and PBOO conditions and graded increases in bladder volume significantly reduced renal blood flow and cortical microvascular blood flow. The acute urinary retention-induced renal vasoconstriction was mediated by the renal nerve. Renal denervation, but not bilateral ureteral resection, abolished the renal vasoconstriction associated with the vesicovascular reflexes. 5. These findings indicate that exaggerated activation of bladder afferents exerts a positive feedback effect to increase sympathetic outflow to the kidney further, thereby contributing to significant renal vasoconstriction via a renal nerve-dependent mechanism.

Original languageEnglish
Pages (from-to)397-408
Number of pages12
JournalJournal of Physiology
Volume526
Issue number2
DOIs
Publication statusPublished - 2000 Jul 15

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Urinary Retention
Reflex
Urinary Bladder Neck Obstruction
Hemodynamics
Kidney
Urinary Bladder
Vasoconstriction
Mechanoreceptors
Arterial Pressure
Urination
Renal Circulation
Denervation
Vascular Resistance
Ligation
Wistar Rats
Pressure

ASJC Scopus subject areas

  • Physiology

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Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention. / Chien, Chiang-Ting; Yu, Hong Jeng; Cheng, Ya Jung; Wu, Ming Shiou; Chen, Chau Fong; Hsu, Su Ming.

In: Journal of Physiology, Vol. 526, No. 2, 15.07.2000, p. 397-408.

Research output: Contribution to journalArticle

Chien, Chiang-Ting ; Yu, Hong Jeng ; Cheng, Ya Jung ; Wu, Ming Shiou ; Chen, Chau Fong ; Hsu, Su Ming. / Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention. In: Journal of Physiology. 2000 ; Vol. 526, No. 2. pp. 397-408.
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