Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols

Hsyueh Liang Wu; Chiung An Chang; Ping Yu Wu; Biing Jiun Uang

doi:10.1016/j.tetlet.2017.01.034

Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols

Hsyueh Liang Wu^*, Chiung An Chang, Ping Yu Wu, Biing Jiun Uang

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Zn-catalyzed asymmetric alkylation reaction with carbonyl compounds has provided a straightforward method to access enantio-enriched tertiary alcohols. This chiral carbon-carbon bond forming process has attracted great attention in the field of asymmetric synthesis with features of mild reaction conditions, tolerating diverse functional groups and employment of low toxic zinc metal. In this digest, the recent developments of this asymmetric protocol are focused.

Original language	English
Pages (from-to)	706-710
Number of pages	5
Journal	Tetrahedron Letters
Volume	58
Issue number	8
DOIs	https://doi.org/10.1016/j.tetlet.2017.01.034
Publication status	Published - 2017

Keywords

Chiral tertiary alcohols
Enantioselective catalysis
Zn-catalyzed asymmetric addition

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2017.01.034

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abstract = "Zn-catalyzed asymmetric alkylation reaction with carbonyl compounds has provided a straightforward method to access enantio-enriched tertiary alcohols. This chiral carbon-carbon bond forming process has attracted great attention in the field of asymmetric synthesis with features of mild reaction conditions, tolerating diverse functional groups and employment of low toxic zinc metal. In this digest, the recent developments of this asymmetric protocol are focused.",

keywords = "Chiral tertiary alcohols, Enantioselective catalysis, Zn-catalyzed asymmetric addition",

author = "Wu, {Hsyueh Liang} and Chang, {Chiung An} and Wu, {Ping Yu} and Uang, {Biing Jiun}",

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AU - Chang, Chiung An

AU - Wu, Ping Yu

AU - Uang, Biing Jiun

PY - 2017

Y1 - 2017

N2 - Zn-catalyzed asymmetric alkylation reaction with carbonyl compounds has provided a straightforward method to access enantio-enriched tertiary alcohols. This chiral carbon-carbon bond forming process has attracted great attention in the field of asymmetric synthesis with features of mild reaction conditions, tolerating diverse functional groups and employment of low toxic zinc metal. In this digest, the recent developments of this asymmetric protocol are focused.

AB - Zn-catalyzed asymmetric alkylation reaction with carbonyl compounds has provided a straightforward method to access enantio-enriched tertiary alcohols. This chiral carbon-carbon bond forming process has attracted great attention in the field of asymmetric synthesis with features of mild reaction conditions, tolerating diverse functional groups and employment of low toxic zinc metal. In this digest, the recent developments of this asymmetric protocol are focused.

KW - Chiral tertiary alcohols

KW - Enantioselective catalysis

KW - Zn-catalyzed asymmetric addition

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Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols

Abstract

Keywords

ASJC Scopus subject areas

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