Recent developments in Zn-catalyzed asymmetric addition reaction to ketones: Syntheses of chiral tertiary alcohols

Hsyueh Liang Wu, Chiung An Chang, Ping Yu Wu, Biing Jiun Uang

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Zn-catalyzed asymmetric alkylation reaction with carbonyl compounds has provided a straightforward method to access enantio-enriched tertiary alcohols. This chiral carbon-carbon bond forming process has attracted great attention in the field of asymmetric synthesis with features of mild reaction conditions, tolerating diverse functional groups and employment of low toxic zinc metal. In this digest, the recent developments of this asymmetric protocol are focused.

Original languageEnglish
Pages (from-to)706-710
Number of pages5
JournalTetrahedron Letters
Volume58
Issue number8
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Chiral tertiary alcohols
  • Enantioselective catalysis
  • Zn-catalyzed asymmetric addition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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