Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products

Ramani Gurubrahamam; You Song Cheng; Wan Yun Huang; Kwunmin Chen

doi:10.1002/cctc.201500455

Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products

Ramani Gurubrahamam, You Song Cheng, Wan Yun Huang, Kwunmin Chen^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

This Minireview describes organocatalytic kinetic resolution (OCKR) that has evolved on the basis of using small organic catalysts through enamine/iminium ion, N-heterocyclic carbene, and hydrogen-bonding catalysis. The review includes the use of recent methodologies for which the evolution of OCKR mainly involves creating new stereogenic center(s) in functionalized products through the formation of a C-C, C-N, C-O, C-X, or C-S bond. The combination of OCKR with sequential reactions and its association with desymmetrization and dynamic kinetic resolution are also described.

Original language	English
Pages (from-to)	86-96
Number of pages	11
Journal	ChemCatChem
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/cctc.201500455
Publication status	Published - 2016 Jan 7

Keywords

chirality
desymmetrization
domino reactions
kinetic resolution
organocatalysis

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1002/cctc.201500455

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abstract = "This Minireview describes organocatalytic kinetic resolution (OCKR) that has evolved on the basis of using small organic catalysts through enamine/iminium ion, N-heterocyclic carbene, and hydrogen-bonding catalysis. The review includes the use of recent methodologies for which the evolution of OCKR mainly involves creating new stereogenic center(s) in functionalized products through the formation of a C-C, C-N, C-O, C-X, or C-S bond. The combination of OCKR with sequential reactions and its association with desymmetrization and dynamic kinetic resolution are also described.",

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Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products

Abstract

Keywords

ASJC Scopus subject areas

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