Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products

Ramani Gurubrahamam, You Song Cheng, Wan Yun Huang, Kwunmin Chen

Research output: Contribution to journalReview article

21 Citations (Scopus)


This Minireview describes organocatalytic kinetic resolution (OCKR) that has evolved on the basis of using small organic catalysts through enamine/iminium ion, N-heterocyclic carbene, and hydrogen-bonding catalysis. The review includes the use of recent methodologies for which the evolution of OCKR mainly involves creating new stereogenic center(s) in functionalized products through the formation of a C-C, C-N, C-O, C-X, or C-S bond. The combination of OCKR with sequential reactions and its association with desymmetrization and dynamic kinetic resolution are also described.

Original languageEnglish
Pages (from-to)86-96
Number of pages11
Issue number1
Publication statusPublished - 2016 Jan 7



  • chirality
  • desymmetrization
  • domino reactions
  • kinetic resolution
  • organocatalysis

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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