Reactions of β-nitrostyrenes with Grignard reagents

Ching Fa Yao*, Wen Chang Chen, Yu Mei Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


α-Phenyl-β-nitrostyrene 1a and β-nitrostyrene 1b react with Grignard reagents to generate hydroxyimoyl halides 3 or nitrile oxides 4 after workup with ice cold concentrated aqueous HX acid solution. Carboxylic acids 5 are the only products isolated from 1b and products 3 or 4 are still obtained from 1a when concentrated sulfuric acid solution is used.

Original languageEnglish
Pages (from-to)6339-6342
Number of pages4
JournalTetrahedron Letters
Issue number35
Publication statusPublished - 1996 Aug 26

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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