Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of L-dopa

Yu Hsuan Lin, Yi Chun Yeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

L-dopa is a catecholamine neurotransmitter used to treat Parkinson's disease. This paper presents a low-cost paper-based biosensor aimed at enhancing the convenience of monitoring L-dopa concentrations. ZnO nanorods (ZnO-NRs) were synthesized on papers in less than 90 min using a microwave-assisted hydrothermal method. The ZnO-NRs amplify green fluorescence signals to enhance the detection sensitivity of L-dopa, best measured at excitation/emission wavelengths of 475/537 nm. We systematically characterized the effect of reaction conditions on the corresponding fluorescence enhancements. The proposed ZnO NRs-paper biosensor presented a ∼3-fold increase in green fluorescence compared to unmodified papers. The linear range of detection for L-dopa was 25–2000 nM, with a limit of detection of 24 nM, which meets the clinical requirements for the monitoring of L-dopa in Parkinson's patients.

Original languageEnglish
Article number111995
JournalColloids and Surfaces B: Biointerfaces
Volume207
DOIs
Publication statusPublished - 2021 Nov

Keywords

  • Fluorescence enhancement
  • Fluorometric detection
  • L-dopa
  • Microwave-assisted
  • Paper-based
  • ZnO nanorods

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'Rapid synthesis of microwave-assisted zinc oxide nanorods on a paper-based analytical device for fluorometric detection of L-dopa'. Together they form a unique fingerprint.

Cite this