Rapid screening and determination of designer drugs in saliva by a nib-assisted paper spray-mass spectrometry and separation technique

Hsun Lee, Chih Sheng Jhang, Ju Tsung Liu, Cheng Huang Lin

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24 Citations (Scopus)


A method for the rapid screening and determination of amphetamine-type designer drugs in saliva by a novel nib-assisted paper spray-mass spectrometry procedure is described. Under optimized conditions, the limit of detections for amphetamine derivatives (model samples: o-, m-, p-chloroamphetamine and o-, m-, p-fluoroamphetamine, respectively) were determined to 0.1 μg/mL by the nib-assisted paper spray-mass spectrometry method. This method is easier and has a higher sensitivity than similar methodologies, including atmospheric pressure/matrix-assisted laser desorption ionization mass spectrometry and electrospray-assisted laser desorption ionization/mass spectrometry. Data obtained using more classical separation methods, including liquid chromatography and capillary electrophoresis, are also reported.

Original languageEnglish
Pages (from-to)2822-2825
Number of pages4
JournalJournal of Separation Science
Issue number20
Publication statusPublished - 2012 Oct 1



  • Amphetamine derivatives
  • Nib-assisted paper spray-mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

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