Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry

Chih Sheng Jhang; Hsun Lee; Yi San He; Ju Tsung Liu; Cheng Huang Lin

doi:10.1002/elps.201200270

Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry

Chih Sheng Jhang, Hsun Lee, Yi San He, Ju Tsung Liu, Cheng Huang Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.

Original language	English
Pages (from-to)	3073-3078
Number of pages	6
Journal	Electrophoresis
Volume	33
Issue number	19-20
DOIs	https://doi.org/10.1002/elps.201200270
Publication status	Published - 2012 Oct

Keywords

4-chloro-amphetamine
CE-ESI-MS
Paper spray

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry

Access to Document

10.1002/elps.201200270

Cite this

@article{4acc8493c741437ba2b8e2ca29ee5687,

title = "Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry",

abstract = "A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.",

keywords = "4-chloro-amphetamine, CE-ESI-MS, Paper spray",

author = "Jhang, {Chih Sheng} and Hsun Lee and He, {Yi San} and Liu, {Ju Tsung} and Lin, {Cheng Huang}",

year = "2012",

month = oct,

doi = "10.1002/elps.201200270",

language = "English",

volume = "33",

pages = "3073--3078",

journal = "Electrophoresis",

issn = "0173-0835",

publisher = "Wiley-VCH Verlag",

number = "19-20",

}

TY - JOUR

T1 - Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry

AU - Jhang, Chih Sheng

AU - Lee, Hsun

AU - He, Yi San

AU - Liu, Ju Tsung

AU - Lin, Cheng Huang

PY - 2012/10

Y1 - 2012/10

N2 - A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.

AB - A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.

KW - 4-chloro-amphetamine

KW - CE-ESI-MS

KW - Paper spray

UR - http://www.scopus.com/inward/record.url?scp=84867690840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867690840&partnerID=8YFLogxK

U2 - 10.1002/elps.201200270

DO - 10.1002/elps.201200270

M3 - Article

C2 - 23002016

AN - SCOPUS:84867690840

SN - 0173-0835

VL - 33

SP - 3073

EP - 3078

JO - Electrophoresis

JF - Electrophoresis

IS - 19-20

ER -

Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this