Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry

An Kai Su; Ju Tsung Liu; Cheng Huang Lin

doi:10.1016/j.talanta.2005.03.013

Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry

An Kai Su
, Ju Tsung Liu
, Cheng Huang Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.

Original language	English
Pages (from-to)	718-724
Number of pages	7
Journal	Talanta
Volume	67
Issue number	4
DOIs	https://doi.org/10.1016/j.talanta.2005.03.013
Publication status	Published - 2005 Oct 15

Keywords

CHCA
CTAB
Clandestine tablet
MALDI-TOF mass spectrometry
Rapid drug-screening

ASJC Scopus subject areas

Analytical Chemistry

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10.1016/j.talanta.2005.03.013

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@article{32ed17ed300e4a9db05128866b0cc246,

title = "Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry",

abstract = "A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.",

keywords = "CHCA, CTAB, Clandestine tablet, MALDI-TOF mass spectrometry, Rapid drug-screening",

author = "Su, \{An Kai\} and Liu, \{Ju Tsung\} and Lin, \{Cheng Huang\}",

note = "Funding Information: This work was supported by a grant from the National Science Council of Taiwan under Contract No. NSC-92-2113-M-003-023. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License Number: ARR089000035).",

year = "2005",

month = oct,

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doi = "10.1016/j.talanta.2005.03.013",

language = "English",

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journal = "Talanta",

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T1 - Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry

AU - Su, An Kai

AU - Liu, Ju Tsung

AU - Lin, Cheng Huang

N1 - Funding Information: This work was supported by a grant from the National Science Council of Taiwan under Contract No. NSC-92-2113-M-003-023. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License Number: ARR089000035).

PY - 2005/10/15

Y1 - 2005/10/15

N2 - A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.

AB - A novel method for the rapid screening of clandestine tablets for drugs by MALDI-TOF mass spectrometry is described. In this method, cetrimonium bromide (CTAB), a surfactant, is added to the conventional α-cyano-4- hydroxycinnamic acid (CHCA) matrix solution used in preparing the MALDI samples. This procedure allows very clean mass spectra to be collected for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4- methylenedioxymethamphetamine (MDMA), caffeine, ketamine and tramadol. The method was used successfully in the rapid drug-screening of some actual clandestine tablets, which had been seized from the illicit market, and can serve as a good complementary method to GC/MS for use in forensic analysis.

KW - CHCA

KW - CTAB

KW - Clandestine tablet

KW - MALDI-TOF mass spectrometry

KW - Rapid drug-screening

UR - https://www.scopus.com/pages/publications/24344450298

UR - https://www.scopus.com/pages/publications/24344450298#tab=citedBy

U2 - 10.1016/j.talanta.2005.03.013

DO - 10.1016/j.talanta.2005.03.013

M3 - Article

AN - SCOPUS:24344450298

SN - 0039-9140

VL - 67

SP - 718

EP - 724

JO - Talanta

JF - Talanta

IS - 4

ER -

Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry

Abstract

Keywords

ASJC Scopus subject areas

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