TY - JOUR
T1 - Rapid analysis of 3,4-methylenedioxymethamphetamine
T2 - A comparison of nonaqueous capillary electrophoresis/fluorescence detection with GC/MS
AU - Fang, Ching
AU - Chung, Yu Lin
AU - Liu, Ju Tsung
AU - Lin, Cheng Huang
N1 - Funding Information:
This work was supported by a grant from the National Science Council of Taiwan under Contract No. NSC-89-2113-M-003-016. Permission was obtained from Pharmaceutical Affairs, Department of Health, Taiwan (License Number: ARR089000035). The authors wish to thank Forensic Science Center (Taiwan Command of the Army Force of Military Police) for generously donating the urine samples and amphetamine standards.
PY - 2002/2/18
Y1 - 2002/2/18
N2 - Because of the increasing use of 3,4-methylenedioxymethamphetamine (3,4-MDMA), a rapid and sensitive analytical technique is required for its detection and determination. Using nonaqueous capillary electrophoresis/fluorescence spectroscopy (NACE/FS) detection, it is possible to determine this drug at the level 0.5ppm without any pre-treatment in less than 5min. After liquid-liquid extraction, the sample can be condensed and a detection limit of 3,4-MDMA in urine of 50ppb (S/N=3) can be achieved. The precision of the method was evaluated by measuring the repeatability and intermediate precision of migration time and the corrected peak height by comparison with a 3,4-MDMA-D5 internal standard. With the conventional GC/MS method, it is necessary to derivatize the 3,4-MDMA before injection and the GC migration time also is in excess of 20min. Therefore, NACE/FS represents a good complementary method to GC/MS for use in forensic analysis.
AB - Because of the increasing use of 3,4-methylenedioxymethamphetamine (3,4-MDMA), a rapid and sensitive analytical technique is required for its detection and determination. Using nonaqueous capillary electrophoresis/fluorescence spectroscopy (NACE/FS) detection, it is possible to determine this drug at the level 0.5ppm without any pre-treatment in less than 5min. After liquid-liquid extraction, the sample can be condensed and a detection limit of 3,4-MDMA in urine of 50ppb (S/N=3) can be achieved. The precision of the method was evaluated by measuring the repeatability and intermediate precision of migration time and the corrected peak height by comparison with a 3,4-MDMA-D5 internal standard. With the conventional GC/MS method, it is necessary to derivatize the 3,4-MDMA before injection and the GC migration time also is in excess of 20min. Therefore, NACE/FS represents a good complementary method to GC/MS for use in forensic analysis.
KW - 3,4-Methylenedioxymethamphetamine (3,4-MDMA)
KW - Gas chromatography/mass spectrometry (GC/MS)
KW - Nonaqueous capillary electrophoresis/fluorescence spectroscopy (NACE/FS)
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U2 - 10.1016/S0379-0738(01)00636-3
DO - 10.1016/S0379-0738(01)00636-3
M3 - Article
C2 - 11909656
AN - SCOPUS:0037127385
SN - 0379-0738
VL - 125
SP - 142
EP - 148
JO - Forensic Science International
JF - Forensic Science International
IS - 2-3
ER -