Quick screening of true tyrosinase inhibitors from natural products using tyrosinase-immobilized magnetic nanoparticles and a magnetic microplate: Part II melanogenesis bioactivity

Hwei yan Tsai; Chih Chung Hsieh; Yun Ching Chang; Yi ching Lin; Sung Fang Chen

doi:10.1002/jccs.202100344

Quick screening of true tyrosinase inhibitors from natural products using tyrosinase-immobilized magnetic nanoparticles and a magnetic microplate: Part II melanogenesis bioactivity

Hwei yan Tsai^*, Chih Chung Hsieh, Yun Ching Chang, Yi ching Lin, Sung Fang Chen

^*Corresponding author for this work

Department of Chemistry

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Abstract

We previously reported a rapid method for screening true tyrosinase inhibitors. Here, the identified active component from litchi flower extract was further confirmed using a tyrosinase inhibitory assay and inhibitory effects on melanogenesis of murine melanoma B16-F1 cell to prove its bioactivity. This is the first report regarding the inhibitory effect of abscisic acid on melanogenesis. The crude extraction of litchi flower showed some degree of cell toxicity. This report would also like to remind people who want to use crude extraction of herbs to carefully check their toxicological test reports.

Original language	English
Pages (from-to)	2290-2293
Number of pages	4
Journal	Journal of the Chinese Chemical Society
Volume	68
Issue number	12
DOIs	https://doi.org/10.1002/jccs.202100344
Publication status	Published - 2021 Dec

ASJC Scopus subject areas

General Chemistry

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Quick screening of true tyrosinase inhibitors from natural products using tyrosinase-immobilized magnetic nanoparticles and a magnetic microplate: Part II melanogenesis bioactivity. / Tsai, Hwei yan; Hsieh, Chih Chung; Chang, Yun Ching et al.
In: Journal of the Chinese Chemical Society, Vol. 68, No. 12, 12.2021, p. 2290-2293.

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abstract = "We previously reported a rapid method for screening true tyrosinase inhibitors. Here, the identified active component from litchi flower extract was further confirmed using a tyrosinase inhibitory assay and inhibitory effects on melanogenesis of murine melanoma B16-F1 cell to prove its bioactivity. This is the first report regarding the inhibitory effect of abscisic acid on melanogenesis. The crude extraction of litchi flower showed some degree of cell toxicity. This report would also like to remind people who want to use crude extraction of herbs to carefully check their toxicological test reports.",

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AU - Chen, Sung Fang

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Quick screening of true tyrosinase inhibitors from natural products using tyrosinase-immobilized magnetic nanoparticles and a magnetic microplate: Part II melanogenesis bioactivity

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