QTcheterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease: In comparison with stress myocardial perfusion imaging

Yen Wen Wu, Lung Chun Lin, Wei Kung Tseng, Yen Bin Liu, Hsian Li Kao, Mao Shin Lin, Huei Chun Huang, Shan Ying Wang, Herng Er Horng, Hong Chang Yang, Chau Chung Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: Stress nuclear myocardial perfusion imaging (MPI) is an established method for diagnosis and prognosis of coronary artery disease (CAD). However, radiation exposure limits its clinical application. Magnetocardiography (MCG) has been proposed as a non-contact, rapid and non-radiation technique with high reproducibility. The aim of the study was to evaluate the diagnostic efficacy of rest MCG in CAD comparing to stress MPI.

Methods: We prospectively enrolled 55 patients with suspected CAD (64 ± 10 years) who were scheduled for coronary angiography (CA).MCG, stress 201Tl MPI and CAwere performed within 3 months. The spatial distribution maps of QTcinterval (21 × 21 in resolution) were derived from a 64-channel MCG system (KRISS, Korea). T-wave propagation mapping, repolarization heterogeneity index with QTcdispersion and smoothness index of QTc(SI-QTc) were analyzed, and the diagnostic criteria for CAD were developed based on the receiver operating characteristic (ROC) curve analysis.

Results: Patients with significant CAD (≥ 70% luminal stenosis, n = 36) had higher QTcdispersion and SI-QTcthan controls (both p < 0.05). The diagnostic sensitivity and specificity were 0.8330, 0.6842 for QTcdispersion ≥ 79 ms; 0.7778, 0.6842 for SI-QTc≥ 9.1ms; and 0.8611, 0.6842 for combination. There was no difference of area under ROC curve by using criteria of QTcdispersion ≥ 79 ms, SI-QTc≥ 9.1 ms or combination (0.7588, 0.7310, 0.7727, p = NS), and non-inferior to stress MPI (p = NS).

Conclusions: The QTcheterogeneity parameters of rest MCG yield a good sensitivity and acceptable specificity for detection of CAD, and may provide an alternative to stress MPI without stress and radiation.

Original languageEnglish
Pages (from-to)445-454
Number of pages10
JournalActa Cardiologica Sinica
Volume30
Issue number5
Publication statusPublished - 2014 Sept 1

Keywords

  • Coronary artery disease (CAD)
  • Magnetocardiography (MCG)
  • Myocardial perfusion imaging (MPI)
  • Repolarization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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