QT c heterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease: In comparison with stress myocardial perfusion imaging

Yen Wen Wu, Lung Chun Lin, Wei Kung Tseng, Yen Bin Liu, Hsian Li Kao, Mao Shin Lin, Huei Chun Huang, Shan Ying Wang, Herng-Er Horng, Hong-Chang Yang, Chau Chung Wu

Research output: Contribution to journalArticle

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Abstract

Background: Stress nuclear myocardial perfusion imaging (MPI) is an established method for diagnosis and prognosis of coronary artery disease (CAD). However, radiation exposure limits its clinical application. Magnetocardiography (MCG) has been proposed as a non-contact, rapid and non-radiation technique with high reproducibility. The aim of the study was to evaluate the diagnostic efficacy of rest MCG in CAD comparing to stress MPI.

Methods: We prospectively enrolled 55 patients with suspected CAD (64 ± 10 years) who were scheduled for coronary angiography (CA).MCG, stress 201 Tl MPI and CAwere performed within 3 months. The spatial distribution maps of QT c interval (21 × 21 in resolution) were derived from a 64-channel MCG system (KRISS, Korea). T-wave propagation mapping, repolarization heterogeneity index with QT c dispersion and smoothness index of QT c (SI-QT c ) were analyzed, and the diagnostic criteria for CAD were developed based on the receiver operating characteristic (ROC) curve analysis.

Results: Patients with significant CAD (≥ 70% luminal stenosis, n = 36) had higher QT c dispersion and SI-QT c than controls (both p < 0.05). The diagnostic sensitivity and specificity were 0.8330, 0.6842 for QT c dispersion ≥ 79 ms; 0.7778, 0.6842 for SI-QT c ≥ 9.1ms; and 0.8611, 0.6842 for combination. There was no difference of area under ROC curve by using criteria of QT c dispersion ≥ 79 ms, SI-QT c ≥ 9.1 ms or combination (0.7588, 0.7310, 0.7727, p = NS), and non-inferior to stress MPI (p = NS).

Conclusions: The QT c heterogeneity parameters of rest MCG yield a good sensitivity and acceptable specificity for detection of CAD, and may provide an alternative to stress MPI without stress and radiation.

Original languageEnglish
Pages (from-to)445-454
Number of pages10
JournalActa Cardiologica Sinica
Volume30
Issue number5
Publication statusPublished - 2014 Sep 1

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Magnetocardiography
Myocardial Perfusion Imaging
Coronary Artery Disease
ROC Curve
Sensitivity and Specificity
Korea
Coronary Angiography
Pathologic Constriction
Radiation

Keywords

  • Coronary artery disease (CAD)
  • Magnetocardiography (MCG)
  • Myocardial perfusion imaging (MPI)
  • Repolarization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

QT c heterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease : In comparison with stress myocardial perfusion imaging. / Wu, Yen Wen; Lin, Lung Chun; Tseng, Wei Kung; Liu, Yen Bin; Kao, Hsian Li; Lin, Mao Shin; Huang, Huei Chun; Wang, Shan Ying; Horng, Herng-Er; Yang, Hong-Chang; Wu, Chau Chung.

In: Acta Cardiologica Sinica, Vol. 30, No. 5, 01.09.2014, p. 445-454.

Research output: Contribution to journalArticle

Wu, YW, Lin, LC, Tseng, WK, Liu, YB, Kao, HL, Lin, MS, Huang, HC, Wang, SY, Horng, H-E, Yang, H-C & Wu, CC 2014, 'QT c heterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease: In comparison with stress myocardial perfusion imaging', Acta Cardiologica Sinica, vol. 30, no. 5, pp. 445-454.
Wu, Yen Wen ; Lin, Lung Chun ; Tseng, Wei Kung ; Liu, Yen Bin ; Kao, Hsian Li ; Lin, Mao Shin ; Huang, Huei Chun ; Wang, Shan Ying ; Horng, Herng-Er ; Yang, Hong-Chang ; Wu, Chau Chung. / QT c heterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease : In comparison with stress myocardial perfusion imaging. In: Acta Cardiologica Sinica. 2014 ; Vol. 30, No. 5. pp. 445-454.
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abstract = "Background: Stress nuclear myocardial perfusion imaging (MPI) is an established method for diagnosis and prognosis of coronary artery disease (CAD). However, radiation exposure limits its clinical application. Magnetocardiography (MCG) has been proposed as a non-contact, rapid and non-radiation technique with high reproducibility. The aim of the study was to evaluate the diagnostic efficacy of rest MCG in CAD comparing to stress MPI. Methods: We prospectively enrolled 55 patients with suspected CAD (64 ± 10 years) who were scheduled for coronary angiography (CA).MCG, stress 201 Tl MPI and CAwere performed within 3 months. The spatial distribution maps of QT c interval (21 × 21 in resolution) were derived from a 64-channel MCG system (KRISS, Korea). T-wave propagation mapping, repolarization heterogeneity index with QT c dispersion and smoothness index of QT c (SI-QT c ) were analyzed, and the diagnostic criteria for CAD were developed based on the receiver operating characteristic (ROC) curve analysis. Results: Patients with significant CAD (≥ 70{\%} luminal stenosis, n = 36) had higher QT c dispersion and SI-QT c than controls (both p < 0.05). The diagnostic sensitivity and specificity were 0.8330, 0.6842 for QT c dispersion ≥ 79 ms; 0.7778, 0.6842 for SI-QT c ≥ 9.1ms; and 0.8611, 0.6842 for combination. There was no difference of area under ROC curve by using criteria of QT c dispersion ≥ 79 ms, SI-QT c ≥ 9.1 ms or combination (0.7588, 0.7310, 0.7727, p = NS), and non-inferior to stress MPI (p = NS). Conclusions: The QT c heterogeneity parameters of rest MCG yield a good sensitivity and acceptable specificity for detection of CAD, and may provide an alternative to stress MPI without stress and radiation.",
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T1 - QT c heterogeneity in rest magnetocardiography is sensitive to detect coronary artery disease

T2 - In comparison with stress myocardial perfusion imaging

AU - Wu, Yen Wen

AU - Lin, Lung Chun

AU - Tseng, Wei Kung

AU - Liu, Yen Bin

AU - Kao, Hsian Li

AU - Lin, Mao Shin

AU - Huang, Huei Chun

AU - Wang, Shan Ying

AU - Horng, Herng-Er

AU - Yang, Hong-Chang

AU - Wu, Chau Chung

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Stress nuclear myocardial perfusion imaging (MPI) is an established method for diagnosis and prognosis of coronary artery disease (CAD). However, radiation exposure limits its clinical application. Magnetocardiography (MCG) has been proposed as a non-contact, rapid and non-radiation technique with high reproducibility. The aim of the study was to evaluate the diagnostic efficacy of rest MCG in CAD comparing to stress MPI. Methods: We prospectively enrolled 55 patients with suspected CAD (64 ± 10 years) who were scheduled for coronary angiography (CA).MCG, stress 201 Tl MPI and CAwere performed within 3 months. The spatial distribution maps of QT c interval (21 × 21 in resolution) were derived from a 64-channel MCG system (KRISS, Korea). T-wave propagation mapping, repolarization heterogeneity index with QT c dispersion and smoothness index of QT c (SI-QT c ) were analyzed, and the diagnostic criteria for CAD were developed based on the receiver operating characteristic (ROC) curve analysis. Results: Patients with significant CAD (≥ 70% luminal stenosis, n = 36) had higher QT c dispersion and SI-QT c than controls (both p < 0.05). The diagnostic sensitivity and specificity were 0.8330, 0.6842 for QT c dispersion ≥ 79 ms; 0.7778, 0.6842 for SI-QT c ≥ 9.1ms; and 0.8611, 0.6842 for combination. There was no difference of area under ROC curve by using criteria of QT c dispersion ≥ 79 ms, SI-QT c ≥ 9.1 ms or combination (0.7588, 0.7310, 0.7727, p = NS), and non-inferior to stress MPI (p = NS). Conclusions: The QT c heterogeneity parameters of rest MCG yield a good sensitivity and acceptable specificity for detection of CAD, and may provide an alternative to stress MPI without stress and radiation.

AB - Background: Stress nuclear myocardial perfusion imaging (MPI) is an established method for diagnosis and prognosis of coronary artery disease (CAD). However, radiation exposure limits its clinical application. Magnetocardiography (MCG) has been proposed as a non-contact, rapid and non-radiation technique with high reproducibility. The aim of the study was to evaluate the diagnostic efficacy of rest MCG in CAD comparing to stress MPI. Methods: We prospectively enrolled 55 patients with suspected CAD (64 ± 10 years) who were scheduled for coronary angiography (CA).MCG, stress 201 Tl MPI and CAwere performed within 3 months. The spatial distribution maps of QT c interval (21 × 21 in resolution) were derived from a 64-channel MCG system (KRISS, Korea). T-wave propagation mapping, repolarization heterogeneity index with QT c dispersion and smoothness index of QT c (SI-QT c ) were analyzed, and the diagnostic criteria for CAD were developed based on the receiver operating characteristic (ROC) curve analysis. Results: Patients with significant CAD (≥ 70% luminal stenosis, n = 36) had higher QT c dispersion and SI-QT c than controls (both p < 0.05). The diagnostic sensitivity and specificity were 0.8330, 0.6842 for QT c dispersion ≥ 79 ms; 0.7778, 0.6842 for SI-QT c ≥ 9.1ms; and 0.8611, 0.6842 for combination. There was no difference of area under ROC curve by using criteria of QT c dispersion ≥ 79 ms, SI-QT c ≥ 9.1 ms or combination (0.7588, 0.7310, 0.7727, p = NS), and non-inferior to stress MPI (p = NS). Conclusions: The QT c heterogeneity parameters of rest MCG yield a good sensitivity and acceptable specificity for detection of CAD, and may provide an alternative to stress MPI without stress and radiation.

KW - Coronary artery disease (CAD)

KW - Magnetocardiography (MCG)

KW - Myocardial perfusion imaging (MPI)

KW - Repolarization

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