A simple and convenient strategy was developed to synthesize a new class of pyrrolidinyl-camphor based bifunctional organocatalysts possessing varying functional linkers. Catalytic screening of these camphor-pyrrolidine linked derivatives for asymmetric Michael reaction of cyclohexanone with β-nitrostyrene was carried out. Various aryl- and heteroaryl-nitroolefins, ketones as well as aldehydes gave the corresponding Michael adducts in high chemical yields (up to 95%) and exceptionally high diastereo-(syn/anti up to 99:1) and enantioselectivity (up to 95%) using catalyst 6 under solvent-free conditions.
|Number of pages||7|
|Publication status||Published - 2011 Feb 11|
- Michael addition
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
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CCDC 796818: Experimental Crystal Structure Determination
Anwar, S. (Creator), Lee, P. (Creator), Chou, T. (Creator), Chang, C. (Creator) & Chen, K. (Creator), Unknown Publisher, 2011
DOI: 10.5517/ccvr4tj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvr4tj&sid=DataCite