Protective effects of vescalagin from Pink wax apple [ Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats

Wen Chang Chang, Szu-Chuan Shen, James Swi Bea Wu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The unbalance of glucose metabolism in humans may cause the excessive formation of methylglyoxal (MG), which can react with various biomolecules to form the precursor of advanced glycation end products (AGEs). Vescalagin (VES) is an ellagitannin that alleviates insulin resistance in cell study. Results showed that VES reduced the value of oral glucose tolerance test, cardiovascular risk index, AGEs, and tumor necrosis factor-α contents while increasing C-peptide and d-lactate contents significantly in rats orally administered MG and VES together. The preventive effect of VES on MG-induced inflammation and carbohydrate metabolic disorder in rats was thus proved. On the basis of the experiment data, a mechanism, which involves the increase in d-lactate to retard AGE formation and the decrease in cytokine release to prevent β-cell damage, is proposed to explain the bioactivities of VES in antiglycation and in the alleviation of MG-induced carbohydrate metabolic disorder in rats.

Original languageEnglish
Pages (from-to)7102-7109
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume61
Issue number29
DOIs
Publication statusPublished - 2013 Jul 24

Keywords

  • antiglycation
  • carbohydrate metabolic disorder
  • inflammation
  • methylglyoxal
  • vescalagin

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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