Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

Wenchang Chang; Dawei Huang; Y. Martin Lo; Qinqiao Tee; Poling Kuo; James Swibea Wu; Wenchung Huang; Szuchuan Shen

doi:10.1021/acs.jafc.9b02078

Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

Wenchang Chang, Dawei Huang, Y. Martin Lo, Qinqiao Tee, Poling Kuo, James Swibea Wu, Wenchung Huang, Szuchuan Shen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (GSK3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme were attenuated, subsequently lowering the level of β-amyloid 1-42 (Aβ 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.

Original language	English
Pages (from-to)	7684-7693
Number of pages	10
Journal	Journal of Agricultural and Food Chemistry
Volume	67
Issue number	27
DOIs	https://doi.org/10.1021/acs.jafc.9b02078
Publication status	Published - 2019 Jul 10

Keywords

Alzheimer's disease
caffeic acid
cerebral carbohydrate metabolism
hyperinsulinemic

ASJC Scopus subject areas

General Chemistry
General Agricultural and Biological Sciences

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10.1021/acs.jafc.9b02078

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Chang, W., Huang, D., Lo, Y. M., Tee, Q., Kuo, P., Wu, J. S., Huang, W., & Shen, S. (2019). Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats. Journal of Agricultural and Food Chemistry, 67(27), 7684-7693. https://doi.org/10.1021/acs.jafc.9b02078

Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats. / Chang, Wenchang; Huang, Dawei; Lo, Y. Martin et al.
In: Journal of Agricultural and Food Chemistry, Vol. 67, No. 27, 10.07.2019, p. 7684-7693.

Research output: Contribution to journal › Article › peer-review

Chang, W, Huang, D, Lo, YM, Tee, Q, Kuo, P, Wu, JS, Huang, W & Shen, S 2019, 'Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats', Journal of Agricultural and Food Chemistry, vol. 67, no. 27, pp. 7684-7693. https://doi.org/10.1021/acs.jafc.9b02078

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abstract = "This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (GSK3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme were attenuated, subsequently lowering the level of β-amyloid 1-42 (Aβ 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.",

keywords = "Alzheimer's disease, caffeic acid, cerebral carbohydrate metabolism, hyperinsulinemic",

author = "Wenchang Chang and Dawei Huang and Lo, {Y. Martin} and Qinqiao Tee and Poling Kuo and Wu, {James Swibea} and Wenchung Huang and Szuchuan Shen",

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AU - Lo, Y. Martin

AU - Tee, Qinqiao

AU - Kuo, Poling

AU - Wu, James Swibea

AU - Huang, Wenchung

AU - Shen, Szuchuan

PY - 2019/7/10

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N2 - This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (GSK3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme were attenuated, subsequently lowering the level of β-amyloid 1-42 (Aβ 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.

AB - This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (GSK3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme were attenuated, subsequently lowering the level of β-amyloid 1-42 (Aβ 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.

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Protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

Abstract

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