Propofol infusion shortens and attenuates oxidative stress during one lung ventilation

Chi Hsiang Huang, Yong Pin Wang, Pei Yu Wu, Chiang-Ting Chien, Ya Jung Cheng

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Resuming two lung ventilation (2LV) from one lung ventilation (OLV) has been proven to induce significant oxidative stress, mainly by superoxide release. Although total intravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidant/antioxidant balance. Methods: Thirty patients undergoing thoracic surgery were randomly allocated to the propofol infusion (intravenous) group or isoflurane (inhalational) group after induction and placement of a double lumen endobronchial tube. Reactive oxygen species (ROS) production and total antioxidant status (TAS) were measured during OLV and 2LV manipulations. Blood samples were taken in the lateral position before OLV (T1), immediately before resuming 2LV (T2), and 5 minutes (T3) and 20 minutes (T4) after resuming 2LV, for measurement of ROS. Results: ROS production increased significantly at T3 and T4 in both groups but to a lesser extent in the propofol infusion group. TAS levels increased with time in the propofol group but not in the isoflurane group. Conclusion: Propofol infusion, compared with isoflurane inhalation, attenuates ROS production and limits it for 20 minutes after resuming 2LV from OLV. Propofol infusion may be beneficial to patients with inadequate antioxidant capacity.

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalActa Anaesthesiologica Taiwanica
Volume46
Issue number4
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

One-Lung Ventilation
Propofol
Oxidative Stress
Isoflurane
Reactive Oxygen Species
Antioxidants
Thoracic Surgery
Intravenous Anesthesia
Intravenous Infusions
Oxidants
Superoxides
Inhalation
Anesthetics
Anesthesia
Lung

Keywords

  • Anesthetics
  • Artificial
  • Intravenous
  • Propofol
  • Reactive oxygen species
  • Respiration

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Propofol infusion shortens and attenuates oxidative stress during one lung ventilation. / Huang, Chi Hsiang; Wang, Yong Pin; Wu, Pei Yu; Chien, Chiang-Ting; Cheng, Ya Jung.

In: Acta Anaesthesiologica Taiwanica, Vol. 46, No. 4, 01.01.2008, p. 160-165.

Research output: Contribution to journalArticle

Huang, Chi Hsiang ; Wang, Yong Pin ; Wu, Pei Yu ; Chien, Chiang-Ting ; Cheng, Ya Jung. / Propofol infusion shortens and attenuates oxidative stress during one lung ventilation. In: Acta Anaesthesiologica Taiwanica. 2008 ; Vol. 46, No. 4. pp. 160-165.
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