Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives

Hao Wei Zeng, Ping Yu Wu, Hsyueh Liang Wu

Research output: Contribution to journalReview article


The synthesis and properties of β-amino acids have drawn considerable attention owing to their ubiquitous presence in naturally occurring products of biological importance. While β3-amino acids can be readily prepared from α-amino acids via one-carbon homologation, the synthesis of β2-amino acids generally requires multistep efforts. This review focuses on the recent advances in the synthesis of β2-amino acids and their derivatives from substituted β-nitropropionate analogues obtained from the stereoselective transformation of β-nitroacrylates.

Original languageEnglish
Pages (from-to)2991-3006
Number of pages16
JournalOrganic and Biomolecular Chemistry
Issue number16
Publication statusPublished - 2020 Apr 28

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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