Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives

Hao Wei Zeng, Ping Yu Wu, Hsyueh Liang Wu

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    The synthesis and properties of β-amino acids have drawn considerable attention owing to their ubiquitous presence in naturally occurring products of biological importance. While β3-amino acids can be readily prepared from α-amino acids via one-carbon homologation, the synthesis of β2-amino acids generally requires multistep efforts. This review focuses on the recent advances in the synthesis of β2-amino acids and their derivatives from substituted β-nitropropionate analogues obtained from the stereoselective transformation of β-nitroacrylates.

    Original languageEnglish
    Pages (from-to)2991-3006
    Number of pages16
    JournalOrganic and Biomolecular Chemistry
    Volume18
    Issue number16
    DOIs
    Publication statusPublished - 2020 Apr 28

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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