Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao; Siang En Syu; Yi Wun Jhang; Wenwei Lin

doi:10.1021/ol101080q

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao, Siang En Syu, Yi Wun Jhang, Wenwei Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

Original language	English
Pages (from-to)	3066-3069
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	13
DOIs	https://doi.org/10.1021/ol101080q
Publication status	Published - 2010 Jul 2

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol101080q

Cite this

@article{9801d6869a804d1da05879efc2e45592,

title = "Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates",

abstract = "Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.",

author = "Kao, {Tzu Ting} and Syu, {Siang En} and Jhang, {Yi Wun} and Wenwei Lin",

year = "2010",

month = jul,

day = "2",

doi = "10.1021/ol101080q",

language = "English",

volume = "12",

pages = "3066--3069",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "13",

}

TY - JOUR

T1 - Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

AU - Kao, Tzu Ting

AU - Syu, Siang En

AU - Jhang, Yi Wun

AU - Lin, Wenwei

PY - 2010/7/2

Y1 - 2010/7/2

N2 - Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

AB - Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

UR - http://www.scopus.com/inward/record.url?scp=77954097756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954097756&partnerID=8YFLogxK

U2 - 10.1021/ol101080q

DO - 10.1021/ol101080q

M3 - Article

C2 - 20521775

AN - SCOPUS:77954097756

SN - 1523-7060

VL - 12

SP - 3066

EP - 3069

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

CCDC 769770: Experimental Crystal Structure Determination

CCDC 769220: Experimental Crystal Structure Determination

CCDC 768638: Experimental Crystal Structure Determination

Cite this

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 769770: Experimental Crystal Structure Determination

CCDC 769220: Experimental Crystal Structure Determination

CCDC 768638: Experimental Crystal Structure Determination

Cite this