Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao; Siang En Syu; Yi Wun Jhang; Wenwei Lin

doi:10.1021/ol101080q

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao, Siang En Syu, Yi Wun Jhang, Wenwei Lin

Department of Chemistry

Research output: Contribution to journal › Article

76 Citations (Scopus)

Abstract

Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

Original language	English
Pages (from-to)	3066-3069
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	13
DOIs	https://doi.org/10.1021/ol101080q
Publication status	Published - 2010 Jul 2

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Kao, T. T., Syu, S. E., Jhang, Y. W., & Lin, W. (2010). Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates. Organic Letters, 12(13), 3066-3069. https://doi.org/10.1021/ol101080q

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Access to Document

10.1021/ol101080q