Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao; Siang En Syu; Yi Wun Jhang; Wenwei Lin

doi:10.1021/ol101080q

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao, Siang En Syu, Yi Wun Jhang, Wenwei Lin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

Original language	English
Pages (from-to)	3066-3069
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	13
DOIs	https://doi.org/10.1021/ol101080q
Publication status	Published - 2010 Jul 2

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates",

abstract = "Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.",

author = "Kao, {Tzu Ting} and Syu, {Siang En} and Jhang, {Yi Wun} and Wenwei Lin",

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AU - Kao, Tzu Ting

AU - Syu, Siang En

AU - Jhang, Yi Wun

AU - Lin, Wenwei

PY - 2010/7/2

Y1 - 2010/7/2

N2 - Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

AB - Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

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