Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates

Tzu Ting Kao, Siang En Syu, Yi Wun Jhang, Wenwei Lin

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60-99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.

Original languageEnglish
Pages (from-to)3066-3069
Number of pages4
JournalOrganic Letters
Volume12
Issue number13
DOIs
Publication statusPublished - 2010 Jul 2

Fingerprint

Furans
furans
Phosphorus
phosphorus
preparation
Chlorides
chlorides
Temperature
room temperature
tri-n-butylphosphine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Preparation of tetrasubstituted furans via intramolecular wittig reactions with phosphorus ylides as intermediates. / Kao, Tzu Ting; Syu, Siang En; Jhang, Yi Wun; Lin, Wenwei.

In: Organic Letters, Vol. 12, No. 13, 02.07.2010, p. 3066-3069.

Research output: Contribution to journalArticle

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