Preparation of polyfunctional arynes via 2-magnesiated diaryl sulfonates

Ioannis Sapountzis*, Wenwei Lin, Markus Fischer, Paul Knochel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


The synthetic potential of arynes can be exploited through a new method for their generation from functionalized aryl magnesium reagents and controlled reaction. Arynes with functional groups such as ester, nitrile, ketone, or nitro groups, or with a quinolyl skeleton, can be formed from polyfunctionalized 2-iodo aryl 4-chlorobenezenesulfonates and trapped in 68-93% yield with furan (see scheme).

Original languageEnglish
Pages (from-to)4364-4366
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number33
Publication statusPublished - 2004 Aug 20
Externally publishedYes


  • Arynes
  • Cycloaddition
  • Elimination
  • Grignard reagents
  • Metalation

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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