Abstract
A Bu3P-mediated cyclization reaction of 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones though electrophilic addition of acyl chlorides towards the synthesis of highly functionalized furo[3,2-c]coumarins bearing a phosphorus ylide moiety is described. These unprecedented cyclization reaction proceeds under mild reaction conditions within short reaction times (1 min to 1 h), and can be further applied in the synthesis of alkenyl-substituted furo[3,2-c]coumarins by the treatment with carbonyl electrophiles under basic conditions.
Original language | English |
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Pages (from-to) | 8502-8505 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 29 |
DOIs | |
Publication status | Published - 2015 Jul 13 |
Keywords
- acylation
- cyclizations
- heterocycles
- ylides
- zwitterion
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)