Abstract
Preparation of new types of highly functional benzofurans, benzothiophenes, and indoles is realized via intramolecular Wittig reactions with the corresponding ester, thioester, and amide functionalities. The key intermediates, phosphorus ylides, presumably result from the addition of Bu 3P toward aldehydes followed by acylation and deprotonation. Synthesis of functional benzofurans directly starting from salicylic aldehyde derivatives with acid chlorides in a one-step procedure is also developed.
| Original language | English |
|---|---|
| Pages (from-to) | 2970-2973 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 Jun 3 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Preparation of functional benzofurans, benzothiophenes, and indoles using ester, thioester, and amide via intramolecular wittig reactions. / Syu, Siang En; Lee, Yu Ting; Jang, Yeong Jiunn; Lin, Wenwei.
In: Organic Letters, Vol. 13, No. 11, 03.06.2011, p. 2970-2973.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Preparation of functional benzofurans, benzothiophenes, and indoles using ester, thioester, and amide via intramolecular wittig reactions
AU - Syu, Siang En
AU - Lee, Yu Ting
AU - Jang, Yeong Jiunn
AU - Lin, Wenwei
PY - 2011/6/3
Y1 - 2011/6/3
N2 - Preparation of new types of highly functional benzofurans, benzothiophenes, and indoles is realized via intramolecular Wittig reactions with the corresponding ester, thioester, and amide functionalities. The key intermediates, phosphorus ylides, presumably result from the addition of Bu 3P toward aldehydes followed by acylation and deprotonation. Synthesis of functional benzofurans directly starting from salicylic aldehyde derivatives with acid chlorides in a one-step procedure is also developed.
AB - Preparation of new types of highly functional benzofurans, benzothiophenes, and indoles is realized via intramolecular Wittig reactions with the corresponding ester, thioester, and amide functionalities. The key intermediates, phosphorus ylides, presumably result from the addition of Bu 3P toward aldehydes followed by acylation and deprotonation. Synthesis of functional benzofurans directly starting from salicylic aldehyde derivatives with acid chlorides in a one-step procedure is also developed.
UR - http://www.scopus.com/inward/record.url?scp=79957818897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957818897&partnerID=8YFLogxK
U2 - 10.1021/ol201062r
DO - 10.1021/ol201062r
M3 - Article
C2 - 21563772
AN - SCOPUS:79957818897
VL - 13
SP - 2970
EP - 2973
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 11
ER -