Abstract
Preparation of new types of highly functional benzofurans, benzothiophenes, and indoles is realized via intramolecular Wittig reactions with the corresponding ester, thioester, and amide functionalities. The key intermediates, phosphorus ylides, presumably result from the addition of Bu 3P toward aldehydes followed by acylation and deprotonation. Synthesis of functional benzofurans directly starting from salicylic aldehyde derivatives with acid chlorides in a one-step procedure is also developed.
| Original language | English |
|---|---|
| Pages (from-to) | 2970-2973 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2011 Jun 3 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Syu, S. E., Lee, Y. T., Jang, Y. J., & Lin, W. (2011). Preparation of functional benzofurans, benzothiophenes, and indoles using ester, thioester, and amide via intramolecular wittig reactions. Organic Letters, 13(11), 2970-2973. https://doi.org/10.1021/ol201062r