Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions

Yu Ting Lee; Yeong Jiunn Jang; Siang En Syu; Shu Chi Chou; Chia Jui Lee; Wenwei Lin

doi:10.1039/c2cc33972b

Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions

Yu Ting Lee, Yeong Jiunn Jang, Siang En Syu, Shu Chi Chou, Chia Jui Lee, Wenwei Lin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.

Original language	English
Pages (from-to)	8135-8137
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	65
DOIs	https://doi.org/10.1039/c2cc33972b
Publication status	Published - 2012 Jul 18

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.",

author = "Lee, {Yu Ting} and Jang, {Yeong Jiunn} and Syu, {Siang En} and Chou, {Shu Chi} and Lee, {Chia Jui} and Wenwei Lin",

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AU - Lee, Yu Ting

AU - Jang, Yeong Jiunn

AU - Syu, Siang En

AU - Chou, Shu Chi

AU - Lee, Chia Jui

AU - Lin, Wenwei

PY - 2012/7/18

Y1 - 2012/7/18

N2 - A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.

AB - A general preparation of new types of benzofurans, benzothiophenes and indoles is realized via chemoselective intramolecular Wittig reactions with the corresponding ester, thioester and amide functionalities using in situ formed phosphorus ylides as key intermediates. The reaction conditions are very mild, and numerous Michael acceptors and commercially available acid chlorides can be applied very efficiently in a one-step procedure.

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JF - Chemical Communications

SN - 1359-7345

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ER -

Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions

Abstract

ASJC Scopus subject areas

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