Preparation of fluorescent silica nanotubes and their application in gene delivery

Chia Chun Chen; Yao Chung Liu; Chia Hsuan Wu; Chun Chia Yeh; Ming Tsan Su; Yi Chun Wu

doi:10.1002/adma.200400966

Preparation of fluorescent silica nanotubes and their application in gene delivery

Chia Chun Chen^*, Yao Chung Liu, Chia Hsuan Wu, Chun Chia Yeh, Ming Tsan Su, Yi Chun Wu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

172 Citations (Scopus)

Abstract

The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

Original language	English
Pages (from-to)	404-407
Number of pages	4
Journal	Advanced Materials
Volume	17
Issue number	4
DOIs	https://doi.org/10.1002/adma.200400966
Publication status	Published - 2005 Feb 23

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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AU - Wu, Yi Chun

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Preparation of fluorescent silica nanotubes and their application in gene delivery

Abstract

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