Preparation of fluorescent silica nanotubes and their application in gene delivery

Chia Chun Chen, Yao Chung Liu, Chia Hsuan Wu, Chun Chia Yeh, Ming Tsan Su, Yi Chun Wu

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalAdvanced Materials
Volume17
Issue number4
DOIs
Publication statusPublished - 2005 Feb 23

Fingerprint

Silicon Dioxide
Nanotubes
Genes
Silica
Aluminum Oxide
Membranes
Aluminum
Oxides
Nanocrystals
Sol-gels
DNA

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Preparation of fluorescent silica nanotubes and their application in gene delivery. / Chen, Chia Chun; Liu, Yao Chung; Wu, Chia Hsuan; Yeh, Chun Chia; Su, Ming Tsan; Wu, Yi Chun.

In: Advanced Materials, Vol. 17, No. 4, 23.02.2005, p. 404-407.

Research output: Contribution to journalArticle

Chen, Chia Chun ; Liu, Yao Chung ; Wu, Chia Hsuan ; Yeh, Chun Chia ; Su, Ming Tsan ; Wu, Yi Chun. / Preparation of fluorescent silica nanotubes and their application in gene delivery. In: Advanced Materials. 2005 ; Vol. 17, No. 4. pp. 404-407.
@article{4d04b4fce3fa49cc8b99947789277446,
title = "Preparation of fluorescent silica nanotubes and their application in gene delivery",
abstract = "The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.",
author = "Chen, {Chia Chun} and Liu, {Yao Chung} and Wu, {Chia Hsuan} and Yeh, {Chun Chia} and Su, {Ming Tsan} and Wu, {Yi Chun}",
year = "2005",
month = "2",
day = "23",
doi = "10.1002/adma.200400966",
language = "English",
volume = "17",
pages = "404--407",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "4",

}

TY - JOUR

T1 - Preparation of fluorescent silica nanotubes and their application in gene delivery

AU - Chen, Chia Chun

AU - Liu, Yao Chung

AU - Wu, Chia Hsuan

AU - Yeh, Chun Chia

AU - Su, Ming Tsan

AU - Wu, Yi Chun

PY - 2005/2/23

Y1 - 2005/2/23

N2 - The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

AB - The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

UR - http://www.scopus.com/inward/record.url?scp=14844333199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14844333199&partnerID=8YFLogxK

U2 - 10.1002/adma.200400966

DO - 10.1002/adma.200400966

M3 - Article

AN - SCOPUS:14844333199

VL - 17

SP - 404

EP - 407

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 4

ER -