Preparation of fluorescent silica nanotubes and their application in gene delivery

Chia Chun Chen*, Yao Chung Liu, Chia Hsuan Wu, Chun Chia Yeh, Ming Tsan Su, Yi Chun Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

163 Citations (Scopus)

Abstract

The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalAdvanced Materials
Volume17
Issue number4
DOIs
Publication statusPublished - 2005 Feb 23

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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