Preparation of fluorescent silica nanotubes and their application in gene delivery

Chia Chun Chen, Yao Chung Liu, Chia Hsuan Wu, Chun Chia Yeh, Ming Tsan Su, Yi Chun Wu

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

The synthesis of fluorescent silica nanotubes with an inner diameter of hundreds of nanometer by sol-gel reaction using an anodic aluminum oxide (AAO) membrane as template and their application in gene delivery were discussed. It was found that a commercial AAO membrane with an average pore diameter of about 200 nm was employed as the template for silica nanotube preparation. The CdSe/ZnS core-shell nanocrystals with diameter of about 4 nm and 8 nm respectively were incorporated during nanotube preparation to generate green- and red-fluorescent silica nanotubes. Analysis suggest that the nanotube wall may act as a physical shield that protects the loaded DNA materials from potential environmental damage.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalAdvanced Materials
Volume17
Issue number4
DOIs
Publication statusPublished - 2005 Feb 23

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ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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