Preparation of electrospun alginate fibers with chitosan sheath

Jung Jhih Chang; Yen Hsien Lee; Meng Hsiu Wu; Ming Chien Yang; Chiang Ting Chien

doi:10.1016/j.carbpol.2011.10.054

Preparation of electrospun alginate fibers with chitosan sheath

Jung Jhih Chang, Yen Hsien Lee, Meng Hsiu Wu, Ming Chien Yang^*, Chiang Ting Chien

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

In this study, alginate (AL) fibers were electrospun and coagulated with chitosan (ChS) and ethanol using a single spinneret. These fibers exhibited a core-sheath structure that was revealed using a confocal laser scanning microscope (CLSM) and fluorescence-labeled polymers. The resulting fibers were examined using a field emission scanning electron microscope (FESEM) for the fiber size and morphology. The average diameter of the fibers ranged from 600 to 900 nm depending on the electrospinning parameters. To mimic the stability of alginate fibers in physiological fluids, the release of alginate from these fibers in normal saline was also tested. The results demonstrated that the core-sheath structure of alginate fiber can greatly reduce the degradation by 40% for 3 d in physiological environment.

Original language	English
Pages (from-to)	2357-2361
Number of pages	5
Journal	Carbohydrate Polymers
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/j.carbpol.2011.10.054
Publication status	Published - 2012 Feb 14
Externally published	Yes

Keywords

Chitosan
Core-sheath structure
Electrospinning
Fluorescent labeling
Sodium alginate

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2011.10.054

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title = "Preparation of electrospun alginate fibers with chitosan sheath",

abstract = "In this study, alginate (AL) fibers were electrospun and coagulated with chitosan (ChS) and ethanol using a single spinneret. These fibers exhibited a core-sheath structure that was revealed using a confocal laser scanning microscope (CLSM) and fluorescence-labeled polymers. The resulting fibers were examined using a field emission scanning electron microscope (FESEM) for the fiber size and morphology. The average diameter of the fibers ranged from 600 to 900 nm depending on the electrospinning parameters. To mimic the stability of alginate fibers in physiological fluids, the release of alginate from these fibers in normal saline was also tested. The results demonstrated that the core-sheath structure of alginate fiber can greatly reduce the degradation by 40% for 3 d in physiological environment.",

keywords = "Chitosan, Core-sheath structure, Electrospinning, Fluorescent labeling, Sodium alginate",

author = "Chang, {Jung Jhih} and Lee, {Yen Hsien} and Wu, {Meng Hsiu} and Yang, {Ming Chien} and Chien, {Chiang Ting}",

note = "Funding Information: The authors would like to thank the National Science Council of Taiwan, Republic of China , for financially supporting this research under grants NSC-98-2221-E-011-005-MY2 , and NSC-98-2320-B-002-043-MY3 . The authors would also like to thank National Taiwan University Hospital for providing grant NTUH 100-S1661 .",

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doi = "10.1016/j.carbpol.2011.10.054",

language = "English",

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AU - Chang, Jung Jhih

AU - Lee, Yen Hsien

AU - Wu, Meng Hsiu

AU - Yang, Ming Chien

AU - Chien, Chiang Ting

N1 - Funding Information: The authors would like to thank the National Science Council of Taiwan, Republic of China , for financially supporting this research under grants NSC-98-2221-E-011-005-MY2 , and NSC-98-2320-B-002-043-MY3 . The authors would also like to thank National Taiwan University Hospital for providing grant NTUH 100-S1661 .

PY - 2012/2/14

Y1 - 2012/2/14

N2 - In this study, alginate (AL) fibers were electrospun and coagulated with chitosan (ChS) and ethanol using a single spinneret. These fibers exhibited a core-sheath structure that was revealed using a confocal laser scanning microscope (CLSM) and fluorescence-labeled polymers. The resulting fibers were examined using a field emission scanning electron microscope (FESEM) for the fiber size and morphology. The average diameter of the fibers ranged from 600 to 900 nm depending on the electrospinning parameters. To mimic the stability of alginate fibers in physiological fluids, the release of alginate from these fibers in normal saline was also tested. The results demonstrated that the core-sheath structure of alginate fiber can greatly reduce the degradation by 40% for 3 d in physiological environment.

AB - In this study, alginate (AL) fibers were electrospun and coagulated with chitosan (ChS) and ethanol using a single spinneret. These fibers exhibited a core-sheath structure that was revealed using a confocal laser scanning microscope (CLSM) and fluorescence-labeled polymers. The resulting fibers were examined using a field emission scanning electron microscope (FESEM) for the fiber size and morphology. The average diameter of the fibers ranged from 600 to 900 nm depending on the electrospinning parameters. To mimic the stability of alginate fibers in physiological fluids, the release of alginate from these fibers in normal saline was also tested. The results demonstrated that the core-sheath structure of alginate fiber can greatly reduce the degradation by 40% for 3 d in physiological environment.

KW - Chitosan

KW - Core-sheath structure

KW - Electrospinning

KW - Fluorescent labeling

KW - Sodium alginate

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Preparation of electrospun alginate fibers with chitosan sheath

Abstract

Keywords

ASJC Scopus subject areas

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