Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible

Wanquan Jiang, H. C. Yang, S. Y. Yang, H. E. Horng, J. C. Hung, Y. C. Chen, Chin Yih Hong

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

A chemical co-precipitation method capable of controlling the average size and size distribution of magnetic Fe3O4 nano-particles was developed. It was found that the homogeneous variation of the pH value in the solution plays a role in the size distribution of the synthesized Fe 3O4 particles. In this work, we added urea to the ferrite solution, followed by heating the solution to decompose the urea before titrating a base solution into the ferrite solution. Thus, the variation in pH value in the solution can become uniform, and the uniformity in the particles size can be greatly enhanced. In addition, the average particle size is adjustable via control of the amount of urea decomposing at one time. To be biocompatible, dextran is selected as the surfactant for the Fe 3O4 particles, because of its non-toxicity and high bio-affinity. The desired bio-probes can be coated on the dextran layer through adequate chemical reactions.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalJournal of Magnetism and Magnetic Materials
Volume283
Issue number2-3
DOIs
Publication statusPublished - 2004 Dec 1

Fingerprint

Nanoparticles
nanoparticles
preparation
ureas
Urea
dextrans
Dextran
Dextrans
Ferrite
ferrites
Particle size
Coprecipitation
Surface-Active Agents
affinity
Chemical reactions
chemical reactions
Surface active agents
surfactants
Heating
heating

Keywords

  • Biocompatible
  • Co-precipitation
  • Magnetic particles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible. / Jiang, Wanquan; Yang, H. C.; Yang, S. Y.; Horng, H. E.; Hung, J. C.; Chen, Y. C.; Hong, Chin Yih.

In: Journal of Magnetism and Magnetic Materials, Vol. 283, No. 2-3, 01.12.2004, p. 210-214.

Research output: Contribution to journalArticle

Jiang, Wanquan ; Yang, H. C. ; Yang, S. Y. ; Horng, H. E. ; Hung, J. C. ; Chen, Y. C. ; Hong, Chin Yih. / Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible. In: Journal of Magnetism and Magnetic Materials. 2004 ; Vol. 283, No. 2-3. pp. 210-214.
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