Preparation and properties of bio-compatible magnetic Fe3O4 nanoparticles

H. T. Chan, Y. Y. Do, P. L. Huang*, P. L. Chien, T. S. Chan, R. S. Liu, C. Y. Huang, S. Y. Yang, H. E. Horng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

In this work, we study the preparation and properties of bio-compatible magnetic nanoparticles for immunoassay and DNA detection. The magnetite (Fe3O4) nanoparticles were prepared by a chemical co-precipitation method and dextran was selected as the surfactant to suspend the nanoparticles. Suspended particles associated with avidin followed by biotin were qualitatively analyzed by enzyme-linked immunosorbent assay (ELISA) method. We found further the ethylenediamine blocked activated residual groups efficiently, hence enhancing the attachment of biotin for probing the avidin.

Original languageEnglish
Pages (from-to)e415-e417
JournalJournal of Magnetism and Magnetic Materials
Volume304
Issue number1
DOIs
Publication statusPublished - 2006 Sept

Keywords

  • Avidin
  • Bio-compatible nanoparticles
  • Biotinylated alkaline phosphatase
  • Hybridization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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