Preparation and properties of bio-compatible magnetic Fe3O4 nanoparticles

H. T. Chan, Y. Y. Do, P. L. Huang, P. L. Chien, T. S. Chan, R. S. Liu, C. Y. Huang, S. Y. Yang, H. E. Horng

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


In this work, we study the preparation and properties of bio-compatible magnetic nanoparticles for immunoassay and DNA detection. The magnetite (Fe3O4) nanoparticles were prepared by a chemical co-precipitation method and dextran was selected as the surfactant to suspend the nanoparticles. Suspended particles associated with avidin followed by biotin were qualitatively analyzed by enzyme-linked immunosorbent assay (ELISA) method. We found further the ethylenediamine blocked activated residual groups efficiently, hence enhancing the attachment of biotin for probing the avidin.

Original languageEnglish
Pages (from-to)e415-e417
JournalJournal of Magnetism and Magnetic Materials
Issue number1
Publication statusPublished - 2006 Sep


  • Avidin
  • Bio-compatible nanoparticles
  • Biotinylated alkaline phosphatase
  • Hybridization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics


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