Preparation and properties of bio-compatible magnetic Fe3O4 nanoparticles

H. T. Chan, Y. Y. Do, P. L. Huang, P. L. Chien, T. S. Chan, R. S. Liu, C. Y. Huang, S. Y. Yang, H. E. Horng

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    In this work, we study the preparation and properties of bio-compatible magnetic nanoparticles for immunoassay and DNA detection. The magnetite (Fe3O4) nanoparticles were prepared by a chemical co-precipitation method and dextran was selected as the surfactant to suspend the nanoparticles. Suspended particles associated with avidin followed by biotin were qualitatively analyzed by enzyme-linked immunosorbent assay (ELISA) method. We found further the ethylenediamine blocked activated residual groups efficiently, hence enhancing the attachment of biotin for probing the avidin.

    Original languageEnglish
    Pages (from-to)e415-e417
    JournalJournal of Magnetism and Magnetic Materials
    Volume304
    Issue number1
    DOIs
    Publication statusPublished - 2006 Sep 1

    Keywords

    • Avidin
    • Bio-compatible nanoparticles
    • Biotinylated alkaline phosphatase
    • Hybridization

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics

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