Preparation and properties of bio-compatible magnetic Fe3O4 nanoparticles

H. T. Chan, Y. Y. Do, P. L. Huang, P. L. Chien, T. S. Chan, R. S. Liu, C. Y. Huang, S. Y. Yang, H. E. Horng

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Abstract

In this work, we study the preparation and properties of bio-compatible magnetic nanoparticles for immunoassay and DNA detection. The magnetite (Fe3O4) nanoparticles were prepared by a chemical co-precipitation method and dextran was selected as the surfactant to suspend the nanoparticles. Suspended particles associated with avidin followed by biotin were qualitatively analyzed by enzyme-linked immunosorbent assay (ELISA) method. We found further the ethylenediamine blocked activated residual groups efficiently, hence enhancing the attachment of biotin for probing the avidin.

Original languageEnglish
Pages (from-to)e415-e417
JournalJournal of Magnetism and Magnetic Materials
Volume304
Issue number1
DOIs
Publication statusPublished - 2006 Sep 1

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Keywords

  • Avidin
  • Bio-compatible nanoparticles
  • Biotinylated alkaline phosphatase
  • Hybridization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Chan, H. T., Do, Y. Y., Huang, P. L., Chien, P. L., Chan, T. S., Liu, R. S., Huang, C. Y., Yang, S. Y., & Horng, H. E. (2006). Preparation and properties of bio-compatible magnetic Fe3O4 nanoparticles. Journal of Magnetism and Magnetic Materials, 304(1), e415-e417. https://doi.org/10.1016/j.jmmm.2006.01.126