Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study

Yan Wang, Walter J. Rogan, Hsin Yi Chen, Pau Chung Chen, Pen Hua Su, Hsiao Yen Chen, Shu Li Wang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent. Methods: In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n = 120) and 8 years (n = 120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period. Results: Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of -1.6 (95% confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of -2.1 (95% CI: -3.9, -0.2). Conclusions: We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalInternational Journal of Hygiene and Environmental Health
Volume218
Issue number7
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Taiwan
Cohort Studies
Mothers
Intelligence
Linear Models
Confidence Intervals
Third Pregnancy Trimester
Pregnant Women
High Pressure Liquid Chromatography
Serum

Keywords

  • Children
  • IQ
  • Perfluoroalkyl substances
  • Prenatal exposure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Prenatal exposure to perfluroalkyl substances and children's IQ : The Taiwan maternal and infant cohort study. / Wang, Yan; Rogan, Walter J.; Chen, Hsin Yi; Chen, Pau Chung; Su, Pen Hua; Chen, Hsiao Yen; Wang, Shu Li.

In: International Journal of Hygiene and Environmental Health, Vol. 218, No. 7, 01.10.2015, p. 639-644.

Research output: Contribution to journalArticle

Wang, Yan ; Rogan, Walter J. ; Chen, Hsin Yi ; Chen, Pau Chung ; Su, Pen Hua ; Chen, Hsiao Yen ; Wang, Shu Li. / Prenatal exposure to perfluroalkyl substances and children's IQ : The Taiwan maternal and infant cohort study. In: International Journal of Hygiene and Environmental Health. 2015 ; Vol. 218, No. 7. pp. 639-644.
@article{11619fe742ad433f99ce3540e56fc75a,
title = "Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study",
abstract = "Background: Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent. Methods: In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n = 120) and 8 years (n = 120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period. Results: Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of -1.6 (95{\%} confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of -2.1 (95{\%} CI: -3.9, -0.2). Conclusions: We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.",
keywords = "Children, IQ, Perfluoroalkyl substances, Prenatal exposure",
author = "Yan Wang and Rogan, {Walter J.} and Chen, {Hsin Yi} and Chen, {Pau Chung} and Su, {Pen Hua} and Chen, {Hsiao Yen} and Wang, {Shu Li}",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.ijheh.2015.07.002",
language = "English",
volume = "218",
pages = "639--644",
journal = "International Journal of Hygiene and Environmental Health",
issn = "1438-4639",
publisher = "Urban und Fischer Verlag Jena",
number = "7",

}

TY - JOUR

T1 - Prenatal exposure to perfluroalkyl substances and children's IQ

T2 - The Taiwan maternal and infant cohort study

AU - Wang, Yan

AU - Rogan, Walter J.

AU - Chen, Hsin Yi

AU - Chen, Pau Chung

AU - Su, Pen Hua

AU - Chen, Hsiao Yen

AU - Wang, Shu Li

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent. Methods: In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n = 120) and 8 years (n = 120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period. Results: Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of -1.6 (95% confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of -2.1 (95% CI: -3.9, -0.2). Conclusions: We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.

AB - Background: Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent. Methods: In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n = 120) and 8 years (n = 120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period. Results: Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of -1.6 (95% confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of -2.1 (95% CI: -3.9, -0.2). Conclusions: We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.

KW - Children

KW - IQ

KW - Perfluoroalkyl substances

KW - Prenatal exposure

UR - http://www.scopus.com/inward/record.url?scp=84940597715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940597715&partnerID=8YFLogxK

U2 - 10.1016/j.ijheh.2015.07.002

DO - 10.1016/j.ijheh.2015.07.002

M3 - Article

C2 - 26205657

AN - SCOPUS:84940597715

VL - 218

SP - 639

EP - 644

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 7

ER -