Practical synthesis of 6-aryluridines via palladium(II) acetate catalyzed Suzuki-Miyaura cross-coupling reaction

Yu Chiao Shih, Tun Cheng Chien

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Sugar-protected 6-halouridine derivatives underwent Suzuki-Miyaura cross-coupling reactions with arylboronic acids in the presence of palladium(II) acetate as a catalyst, triphenylphosphine as a ligand, and sodium carbonate as a base. This methodology is applicable to both the C5- and C6-position of uridine and provides a direct access for versatile uridine derivatives.

Original languageEnglish
Pages (from-to)3915-3923
Number of pages9
JournalTetrahedron
Volume67
Issue number21
DOIs
Publication statusPublished - 2011 May 27

Keywords

  • Boronic acid
  • Cross-coupling
  • Nucleoside
  • Suzuki-Miyaura
  • Uridine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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