TY - JOUR
T1 - Population-based cohort study on the increase in the risk for type 2 diabetes mellitus development from nonapnea sleep disorders
AU - Lai, Yun Ju
AU - Lin, Cheng Li
AU - Lin, Ming Chia
AU - Lee, Shih Tan
AU - Sung, Fung Chang
AU - Chang, Yen Jung
AU - Kao, Chia Hung
N1 - Funding Information:
The study was supported in part by the study projects (DMR-101-061 and DMR-100-076) in our hospital and Taiwan Department of Health Clinical Trial and Research Center and for Excellence (DOH102-TD-B-111-004). The study also was supported by the Taiwan Department of Health Cancer Research Center for Excellence (DOH102-TD-C-111-005). The funders played no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study.
PY - 2013/9
Y1 - 2013/9
N2 - Objectives: The evidence concerning the relationship between nonapnea sleep disorders and the risk for type 2 diabetes mellitus (DM) is scant and elusive. Our study aimed to examine if nonapnea sleep disorders increase the risk for DM using a population-based retrospective cohort study from 1997 to 2010. Methods: In the Taiwan's National Health Insurance Research Database (NHIRD), 45,602 patients with nonapnea sleep disorders were identified as the study cohort. The comparison cohort was formed by 91,204 age- and gender-matched controls. Cox proportional hazards regression model was used to estimate the risk for developing DM. Results: In 45,602 patients with nonapnea sleep disorders, 7241 new cases of DM were reported during the follow-up period. The mean follow-up time was 9.04 (standard deviation [SD], 3.33) and 8.96 (SD, 3.47) for the nonapnea sleep disorders cohort and the comparison cohort, respectively. The incidence rate of DM was higher in the nonapnea sleep disorder cohort than in the comparison cohort (17.6 vs 13.3 per 1000 individuals-years). Overall, patients with nonapnea sleep disorders had a higher risk for DM compared to patients without nonapnea sleep disorders (adjusted hazard ratio [HR], 1.05 [95% confidence interval {CI}, 1.02-1.08]). Men with nonapnea sleep disorders had a higher risk for DM than the men in the comparison group (adjusted HR, 1.08 [95% CI, 1.03-1.14]). Among subjects aged less than 40. years, patients with nonapnea sleep disorders had a higher risk for DM than the comparison group (adjusted HR, 1.42 [95% CI, 1.27-1.59]). Compared with the comparison cohort, patients with sleep disturbance had an 11% higher risk for DM (adjusted HR, 1.11 [95% CI, 1.07-1.16]). Conclusion: Compared to patients without nonapnea sleep disorders, patients with nonapnea sleep disorders had a higher risk for developing DM, especially among those who were less than 40. years of age and who had sleep disturbances.
AB - Objectives: The evidence concerning the relationship between nonapnea sleep disorders and the risk for type 2 diabetes mellitus (DM) is scant and elusive. Our study aimed to examine if nonapnea sleep disorders increase the risk for DM using a population-based retrospective cohort study from 1997 to 2010. Methods: In the Taiwan's National Health Insurance Research Database (NHIRD), 45,602 patients with nonapnea sleep disorders were identified as the study cohort. The comparison cohort was formed by 91,204 age- and gender-matched controls. Cox proportional hazards regression model was used to estimate the risk for developing DM. Results: In 45,602 patients with nonapnea sleep disorders, 7241 new cases of DM were reported during the follow-up period. The mean follow-up time was 9.04 (standard deviation [SD], 3.33) and 8.96 (SD, 3.47) for the nonapnea sleep disorders cohort and the comparison cohort, respectively. The incidence rate of DM was higher in the nonapnea sleep disorder cohort than in the comparison cohort (17.6 vs 13.3 per 1000 individuals-years). Overall, patients with nonapnea sleep disorders had a higher risk for DM compared to patients without nonapnea sleep disorders (adjusted hazard ratio [HR], 1.05 [95% confidence interval {CI}, 1.02-1.08]). Men with nonapnea sleep disorders had a higher risk for DM than the men in the comparison group (adjusted HR, 1.08 [95% CI, 1.03-1.14]). Among subjects aged less than 40. years, patients with nonapnea sleep disorders had a higher risk for DM than the comparison group (adjusted HR, 1.42 [95% CI, 1.27-1.59]). Compared with the comparison cohort, patients with sleep disturbance had an 11% higher risk for DM (adjusted HR, 1.11 [95% CI, 1.07-1.16]). Conclusion: Compared to patients without nonapnea sleep disorders, patients with nonapnea sleep disorders had a higher risk for developing DM, especially among those who were less than 40. years of age and who had sleep disturbances.
KW - Cohort study
KW - Diabetes mellitus
KW - Diabetic risk
KW - Insomnia
KW - Nonapnea sleep disorders
KW - Sleep disturbance
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U2 - 10.1016/j.sleep.2013.03.024
DO - 10.1016/j.sleep.2013.03.024
M3 - Article
C2 - 23890955
AN - SCOPUS:84881665976
SN - 1389-9457
VL - 14
SP - 913
EP - 918
JO - Sleep Medicine
JF - Sleep Medicine
IS - 9
ER -
