Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings

Wan Ju Yeh, Shih Min Hsia, Wei Hwa Lee, Chi Hao Wu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

253 Citations (Scopus)


Advanced glycation end products (AGEs) are substances composed of amino groups of proteins and reducing sugars. The initial and propagation phases of the glycation process are accompanied by the production of a large amount of free radicals, carbonyl species, and reactive dicarbonyl species, of which, methylglyoxal (MG) is the most reactive and can cause dicarbonyl stress, influencing normal physiological functions. In the advanced phase, the production of AGEs and the interaction between AGEs and their receptor, RAGE, are also considered to be among the causes of chronic diseases, oxidative stress, and inflammatory reaction. Till date, multiple physiological activities of polyphenols have been confirmed. Recently, there have been many studies discussing the ability of polyphenols to suppress the MG and AGEs formation, which was also confirmed in some in vivo studies. This review article collects recent literatures concerning the effects of polyphenols on the generation of MG and AGEs through different pathways and discusses the feasibility of the inhibition of glycative stress and dicarbonyl stress by polyphenols.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalJournal of Food and Drug Analysis
Issue number1
Publication statusPublished - 2017 Jan 1
Externally publishedYes


  • advanced glycation end products
  • antiglycation
  • flavonoid
  • phenolic acid
  • polyphenols

ASJC Scopus subject areas

  • Food Science
  • Pharmacology


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