Plasmonic biosensor detected human chorionic gonadotropin with naked eye

Yu Chieh Yen, Nan Fu Chiu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The traditional surface plasmon resonance (SPR) instrument has the advantages of real time, label-free and high sensitivity. This study mainly makes the traditional SPR instruments miniaturized into active plasmon colorimetric biosensors, which is used for point of care and further improve the medical Level. Nano-printed technology is a simple process technology that used in the preparation of nano-structure with advantages of low cost and high production, for the future active plasmon colorimetric biosensors manufacturing has a very high Production advantages. Organic light emitting diodes have the uniformity of light intensity at different angles, which is one of the indispensable conditions in the detection process of plasmon bioassay. In this experiment, it is proved that the grating period is 555 nm, when the refraction value change from 1 to 1.33 the coupling wavelength shifted about 190 nm, the minimum refractive index is 1.736×10-3 RIU. The binding reaction with β-hCG (1 μM) was enhanced by the bonding of Peptide (1 mM) with gold nanoparticles (15 nm), which was about 43.88 times higher than that of the original peptide (1 mM) and β-hCG (1 μM). That the minimum refraction value of the change in the sensitivity increased to 3.956×10-5 RIU. After the peptides (33 nm) bonded Peptide (1 mM) and β-hCG (1 μM) were used for the active plasmon colorimetric biosensors. The plasmon at a measuring angle of 5 ° wavelength of the emission shifted 16 nm, and the measurement angle is 4 nm at the measuring angle of -5 °.

Original languageEnglish
Title of host publicationOptical Sensors 2019
EditorsFrancesco Baldini, Jiri Homola, Robert A. Lieberman
ISBN (Electronic)9781510627222
Publication statusPublished - 2019
EventOptical Sensors 2019 - Prague, Czech Republic
Duration: 2019 Apr 12019 Apr 4

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceOptical Sensors 2019
Country/TerritoryCzech Republic


  • Biosensors
  • Colorimetric
  • Peptide
  • Surface plasmon resonance (SPR)
  • β-hCG

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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