Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan; Pei Ya Shan; Men Hsin Wu; Pin Han Lin; Chang Shun Tsai; Chia Chien Hsu; Ting Hsiang Chiu; Ting Wei Hsu; Yi Cheun Yeh; Yun Ju Lai; Wei Min Liu; Ling Hsien Tu

doi:10.1039/d3cc03363e

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan
, Pei Ya Shan
, Men Hsin Wu
, Pin Han Lin
, Chang Shun Tsai
, Chia Chien Hsu
, Ting Hsiang Chiu
, Ting Wei Hsu
, Yi Cheun Yeh
, Yun Ju Lai^*
, Wei Min Liu^*
, Ling Hsien Tu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

Original language	English
Pages (from-to)	10660-10663
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	71
DOIs	https://doi.org/10.1039/d3cc03363e
Publication status	Published - 2023 Aug 4

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d3cc03363e

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title = "Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity",

abstract = "Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.",

author = "Chan, \{Ai Ci\} and Shan, \{Pei Ya\} and Wu, \{Men Hsin\} and Lin, \{Pin Han\} and Tsai, \{Chang Shun\} and Hsu, \{Chia Chien\} and Chiu, \{Ting Hsiang\} and Hsu, \{Ting Wei\} and Yeh, \{Yi Cheun\} and Lai, \{Yun Ju\} and Liu, \{Wei Min\} and Tu, \{Ling Hsien\}",

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year = "2023",

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doi = "10.1039/d3cc03363e",

language = "English",

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TY - JOUR

T1 - Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

AU - Chan, Ai Ci

AU - Shan, Pei Ya

AU - Wu, Men Hsin

AU - Lin, Pin Han

AU - Tsai, Chang Shun

AU - Hsu, Chia Chien

AU - Chiu, Ting Hsiang

AU - Hsu, Ting Wei

AU - Yeh, Yi Cheun

AU - Lai, Yun Ju

AU - Liu, Wei Min

AU - Tu, Ling Hsien

PY - 2023/8/4

Y1 - 2023/8/4

N2 - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

AB - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

UR - https://www.scopus.com/pages/publications/85169298607

UR - https://www.scopus.com/pages/publications/85169298607#tab=citedBy

U2 - 10.1039/d3cc03363e

DO - 10.1039/d3cc03363e

M3 - Article

C2 - 37581279

AN - SCOPUS:85169298607

SN - 1359-7345

VL - 59

SP - 10660

EP - 10663

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Abstract

ASJC Scopus subject areas

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