Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan; Pei Ya Shan; Men Hsin Wu; Pin Han Lin; Chang Shun Tsai; Chia Chien Hsu; Ting Hsiang Chiu; Ting Wei Hsu; Yi Cheun Yeh; Yun Ju Lai; Wei Min Liu; Ling Hsien Tu

doi:10.1039/d3cc03363e

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Ai Ci Chan, Pei Ya Shan, Men Hsin Wu, Pin Han Lin, Chang Shun Tsai, Chia Chien Hsu, Ting Hsiang Chiu, Ting Wei Hsu, Yi Cheun Yeh, Yun Ju Lai^*, Wei Min Liu^*, Ling Hsien Tu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

Original language	English
Pages (from-to)	10660-10663
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	71
DOIs	https://doi.org/10.1039/d3cc03363e
Publication status	Published - 2023 Aug 4

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/d3cc03363e

Cite this

@article{f7a3bd27417b4cd8af25ca9df0898651,

title = "Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity",

abstract = "Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.",

author = "Chan, {Ai Ci} and Shan, {Pei Ya} and Wu, {Men Hsin} and Lin, {Pin Han} and Tsai, {Chang Shun} and Hsu, {Chia Chien} and Chiu, {Ting Hsiang} and Hsu, {Ting Wei} and Yeh, {Yi Cheun} and Lai, {Yun Ju} and Liu, {Wei Min} and Tu, {Ling Hsien}",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = aug,

day = "4",

doi = "10.1039/d3cc03363e",

language = "English",

volume = "59",

pages = "10660--10663",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "71",

}

TY - JOUR

T1 - Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

AU - Chan, Ai Ci

AU - Shan, Pei Ya

AU - Wu, Men Hsin

AU - Lin, Pin Han

AU - Tsai, Chang Shun

AU - Hsu, Chia Chien

AU - Chiu, Ting Hsiang

AU - Hsu, Ting Wei

AU - Yeh, Yi Cheun

AU - Lai, Yun Ju

AU - Liu, Wei Min

AU - Tu, Ling Hsien

PY - 2023/8/4

Y1 - 2023/8/4

N2 - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

AB - Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

UR - http://www.scopus.com/inward/record.url?scp=85169298607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85169298607&partnerID=8YFLogxK

U2 - 10.1039/d3cc03363e

DO - 10.1039/d3cc03363e

M3 - Article

C2 - 37581279

AN - SCOPUS:85169298607

SN - 1359-7345

VL - 59

SP - 10660

EP - 10663

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this