Phytochemical constituents from dietary plant Citrus hystrix

Mathusalini Sadasivam; Chandraprakash Kumarasamy; Arasakumar Thangaraj; Mani Govindan; Gayathri Kasirajan; Viswanathan Vijayan; Velmurugan Devadasan; Lin Chia-Her; Gogul Ramnath Madhusudhanan; Thirugnanasampandan Ramaraj; Mohan Palathurai Subramaniam

doi:10.1080/14786419.2017.1399386

Phytochemical constituents from dietary plant Citrus hystrix

Mathusalini Sadasivam, Chandraprakash Kumarasamy, Arasakumar Thangaraj, Mani Govindan, Gayathri Kasirajan, Viswanathan Vijayan, Velmurugan Devadasan, Lin Chia-Her, Gogul Ramnath Madhusudhanan, Thirugnanasampandan Ramaraj, Mohan Palathurai Subramaniam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.

Original language	English
Pages (from-to)	1721-1726
Number of pages	6
Journal	Natural Product Research
Volume	32
Issue number	14
DOIs	https://doi.org/10.1080/14786419.2017.1399386
Publication status	Published - 2018 Jul 18
Externally published	Yes

Keywords

Citrus hystrix
Pyranoflavones
acetylcholinesterase inhibitory activities
antioxidant
cytotoxicity
α-amylase

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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title = "Phytochemical constituents from dietary plant Citrus hystrix",

abstract = "Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.",

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AU - Sadasivam, Mathusalini

AU - Kumarasamy, Chandraprakash

AU - Thangaraj, Arasakumar

AU - Govindan, Mani

AU - Kasirajan, Gayathri

AU - Vijayan, Viswanathan

AU - Devadasan, Velmurugan

AU - Chia-Her, Lin

AU - Madhusudhanan, Gogul Ramnath

AU - Ramaraj, Thirugnanasampandan

AU - Palathurai Subramaniam, Mohan

PY - 2018/7/18

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AB - Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.

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KW - antioxidant

KW - cytotoxicity

KW - α-amylase

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Phytochemical constituents from dietary plant Citrus hystrix

Abstract

Keywords

ASJC Scopus subject areas

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