Phytochemical constituents from dietary plant Citrus hystrix

Mathusalini Sadasivam, Chandraprakash Kumarasamy, Arasakumar Thangaraj, Mani Govindan, Gayathri Kasirajan, Viswanathan Vijayan, Velmurugan Devadasan, Lin Chia-Her, Gogul Ramnath Madhusudhanan, Thirugnanasampandan Ramaraj, Mohan Palathurai Subramaniam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4′-trihydroxypyranoflavone I and 5,4′-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I–VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.

Original languageEnglish
Pages (from-to)1721-1726
Number of pages6
JournalNatural Product Research
Volume32
Issue number14
DOIs
Publication statusPublished - 2018 Jul 18
Externally publishedYes

Keywords

  • Citrus hystrix
  • Pyranoflavones
  • acetylcholinesterase inhibitory activities
  • antioxidant
  • cytotoxicity
  • α-amylase

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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