Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen; Ling Ru Kuo; Shin Yu Lee; Yeu Kuang Hwu; Shang Wei Chou; Chia Chun Chen; Fu Hsiung Chang; Kung Hsuan Lin; Dzung Han Tsai; Yang Yuan Chen

doi:10.1016/j.biomaterials.2012.10.044

Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen, Ling Ru Kuo, Shin Yu Lee, Yeu Kuang Hwu, Shang Wei Chou, Chia Chun Chen, Fu Hsiung Chang, Kung Hsuan Lin, Dzung Han Tsai, Yang Yuan Chen^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

Original language	English
Pages (from-to)	1128-1134
Number of pages	7
Journal	Biomaterials
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.biomaterials.2012.10.044
Publication status	Published - 2013 Jan

Keywords

Cancer therapy
FePt
Laser
Nanoparticle
Photothermal therapy
Thermal lens

ASJC Scopus subject areas

Mechanics of Materials
Ceramics and Composites
Bioengineering
Biophysics
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2012.10.044

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title = "Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles",

abstract = "FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.",

keywords = "Cancer therapy, FePt, Laser, Nanoparticle, Photothermal therapy, Thermal lens",

author = "Chen, {Cheng Lung} and Kuo, {Ling Ru} and Lee, {Shin Yu} and Hwu, {Yeu Kuang} and Chou, {Shang Wei} and Chen, {Chia Chun} and Chang, {Fu Hsiung} and Lin, {Kung Hsuan} and Tsai, {Dzung Han} and Chen, {Yang Yuan}",

note = "Funding Information: This work was supported by the National Science Council of the Republic of China under Grant No. NSC 100-2120-M-001-0019-MY3 . We thank Mr. Hong-Chi Chen for his help with microchamber fabrications, Dr.Chi-Keung Chan for his help with UV–visible absorption spectra analysis, Ms. Shu-Chen Shen for her help with confocal imaging analysis, and Mr. Cheng-Kuang Huang for his important contribution to the research effort.",

year = "2013",

month = jan,

doi = "10.1016/j.biomaterials.2012.10.044",

language = "English",

volume = "34",

pages = "1128--1134",

journal = "Biomaterials",

issn = "0142-9612",

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AU - Chen, Cheng Lung

AU - Kuo, Ling Ru

AU - Lee, Shin Yu

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AU - Chou, Shang Wei

AU - Chen, Chia Chun

AU - Chang, Fu Hsiung

AU - Lin, Kung Hsuan

AU - Tsai, Dzung Han

AU - Chen, Yang Yuan

N1 - Funding Information: This work was supported by the National Science Council of the Republic of China under Grant No. NSC 100-2120-M-001-0019-MY3 . We thank Mr. Hong-Chi Chen for his help with microchamber fabrications, Dr.Chi-Keung Chan for his help with UV–visible absorption spectra analysis, Ms. Shu-Chen Shen for her help with confocal imaging analysis, and Mr. Cheng-Kuang Huang for his important contribution to the research effort.

PY - 2013/1

Y1 - 2013/1

N2 - FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

AB - FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

KW - Cancer therapy

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KW - Laser

KW - Nanoparticle

KW - Photothermal therapy

KW - Thermal lens

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Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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