Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles

Cheng Lung Chen, Ling Ru Kuo, Shin Yu Lee, Yeu Kuang Hwu, Shang Wei Chou, Chia Chun Chen, Fu Hsiung Chang, Kung Hsuan Lin, Dzung Han Tsai, Yang Yuan Chen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy.

Original languageEnglish
Pages (from-to)1128-1134
Number of pages7
JournalBiomaterials
Volume34
Issue number4
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Ultrashort pulses
Nanoparticles
Lasers
Neoplasms
Therapeutics
Nanotubes
Laser beam effects
Nanorods
Drug delivery
Gold
Lenses
Magnetic properties
Fever
Hot Temperature
Cells
Infrared radiation
Imaging techniques
Temperature
Pharmaceutical Preparations

Keywords

  • Cancer therapy
  • FePt
  • Laser
  • Nanoparticle
  • Photothermal therapy
  • Thermal lens

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Chen, C. L., Kuo, L. R., Lee, S. Y., Hwu, Y. K., Chou, S. W., Chen, C. C., ... Chen, Y. Y. (2013). Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles. Biomaterials, 34(4), 1128-1134. https://doi.org/10.1016/j.biomaterials.2012.10.044

Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles. / Chen, Cheng Lung; Kuo, Ling Ru; Lee, Shin Yu; Hwu, Yeu Kuang; Chou, Shang Wei; Chen, Chia Chun; Chang, Fu Hsiung; Lin, Kung Hsuan; Tsai, Dzung Han; Chen, Yang Yuan.

In: Biomaterials, Vol. 34, No. 4, 01.01.2013, p. 1128-1134.

Research output: Contribution to journalArticle

Chen, CL, Kuo, LR, Lee, SY, Hwu, YK, Chou, SW, Chen, CC, Chang, FH, Lin, KH, Tsai, DH & Chen, YY 2013, 'Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles', Biomaterials, vol. 34, no. 4, pp. 1128-1134. https://doi.org/10.1016/j.biomaterials.2012.10.044
Chen, Cheng Lung ; Kuo, Ling Ru ; Lee, Shin Yu ; Hwu, Yeu Kuang ; Chou, Shang Wei ; Chen, Chia Chun ; Chang, Fu Hsiung ; Lin, Kung Hsuan ; Tsai, Dzung Han ; Chen, Yang Yuan. / Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles. In: Biomaterials. 2013 ; Vol. 34, No. 4. pp. 1128-1134.
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