Phosphine-mediated MBH-Type/Acyl transfer/wittig sequence for construction of functionalized furo[3,2-c]coumarins

Sandip Sambhaji Vagh, Bo Jhih Hou, Athukuri Edukondalu, Pin Ching Wang, Wenwei Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction is reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which is accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction.

Original languageEnglish
Pages (from-to)842-846
Number of pages5
JournalOrganic Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 2021 Feb 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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