An efficient protocol for the construction of functionalized 3-alkenyl benzofurans is demonstrated under metal-free conditions using catalytic amount of phosphine proceeding an intramolecular Wittig reaction. This one-pot reaction initiated by the phospha-Michael addition of phosphine to O-acylated nitrostyrene, in which phosphine was in-situ-generated from the chemoselective reduction of phosphine oxide with PhSiH3, would provide the phosphorus ylide to result in the aforementioned multifunctionalized benzofuran via O-acylation/nitrous acid elimination/Wittig reaction.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
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Liou, Y. (Contributor), Wang, H. (Contributor), Edukondalu, A. (Contributor) & Lin, W. (Contributor), The Cambridge Structural Database, 2021