Pd(ii)-catalyzed hydroarylations/hydroalkenylations of terminal alkynes: regioselective synthesis of allylic, homoallylic, and 1,3-diene systems

Jivan Shinde, Sundaram Suresh, Veerababurao Kavala, Ching Fa Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A Pd-catalyzed regioselective hydroarylation of terminal alkynes containing a heteroatom has been developed via carbopalladation for the synthesis of allylic ethers, amines, and homoallylic alcohols. Moreover, hydroalkenylation of alkynes produces a variety of stereodefined 1,4-dienes with high regioselectivity. The important features of the present protocol are that it is highly regioselective, operationally rapid, and scalable with a huge substrate scope using only 3 mol% of PdCl2(PPh3)2 catalyst in the presence of a mild base KOAc.

Original languageEnglish
Pages (from-to)3790-3793
Number of pages4
JournalChemical Communications
Volume60
Issue number28
DOIs
Publication statusPublished - 2024 Mar 8

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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